Limited effects of omega-3 supplementation on offspring metabolic and hypothalamic programming under a maternal cafeteria diet

These findings suggest that the maternal cafeteria diet may adversely affect some biochemical parameters in offspring without inducing short-term changes in nutrition-related gene expression. Ω3 supplementation conferred no apparent therapeutic benefit. Limitations include the absence of adiposity measurements and long-term follow-up, which may have influenced outcomes. Further research is needed to explore long-term metabolic consequences and underlying epigenetic mechanisms.