Single-cell and transcriptomic analyses reveal the role of PCDH17 in the non-inflammatory tumor microenvironment of pancreatic cancer
The predominant expression of PCDH17 was observed in endothelial cells, exhibiting a strong association with inflammatory genes and infiltration of immune cells. PCDH17 exhibits potential as a target for regulating the immune-suppressive tumor microenvironment in pancreatic cancer.
Authors
- Hong Wan (ORCID: https://orcid.org/0000-0003-3794-5692)
- Jun Huang (ORCID: https://orcid.org/0000-0002-4798-6191)
- Dashuai Yang (ORCID: https://orcid.org/0009-0009-3157-3550)
- Kun Cao (ORCID: https://orcid.org/0000-0002-7750-3445)
- Jie Xiong (ORCID: https://orcid.org/0000-0002-8402-1719)
- Yong Sun
Institutions
- Anhui Medical University (CN)
- Wuhan University (CN)
- First Affiliated Hospital of Anhui Medical University (CN)
- Renmin Hospital of Wuhan University (CN)
- Third People's Hospital of Hefei (CN)
Publication Details
- Journal
- Frontiers in Endocrinology
- Published
- 2025-05-23
- DOI
- https://doi.org/10.3389/fendo.2025.1559909
- Primary Topic
- Pancreatic and Hepatic Oncology Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00