Investigation of the Influence of Lipoprotein(a) and Oxidized Lipoprotein(a) on Plasminogen Activation and Fibrinolysis
This study demonstrates that while low levels of Lp(a) may support fibrinolysis, oxidized Lp(a) impairs this process by inhibiting plasminogen activation through structural and functional competition. These findings highlight the atherogenic potential of oxidized Lp(a) and its contribution to thrombotic cardiovascular risk.
Authors
- Sergey O. Solomevich (ORCID: https://orcid.org/0000-0001-9053-4855)
- Karthik Dhanabalan (ORCID: https://orcid.org/0000-0002-6619-6363)
- David Gailani (ORCID: https://orcid.org/0000-0001-8142-8014)
- S. Kent Dickeson (ORCID: https://orcid.org/0000-0003-2766-4061)
- Matthew Yao
- Connor W. Dennewitz
- Wen‐Liang Song (ORCID: https://orcid.org/0000-0002-1866-0635)
Institutions
- Vanderbilt University (US)
- Brown University (US)
- Vanderbilt University Medical Center (US)
Publication Details
- Journal
- Journal of Lipid and Atherosclerosis
- Published
- 2025-01-01
- DOI
- https://doi.org/10.12997/jla.2025.14.2.229
- Citations
- 1
- Primary Topic
- Lipoproteins and Cardiovascular Health
- Type
- article
- Field-Weighted Citation Impact
- 2.01
Funders
- Brown University