Changes in immune cell signatures during early infection reflect decoupling of capillary perfusion and glycocalyx dimensions
We demonstrate that glycocalyx damage is associated with a unique immunological signature, distinct from functional capillary density. These findings provide a strong basis for future studies of immune dysregulation and microvascular dysfunction in infection.
Authors
- Philipp Kümpers (ORCID: https://orcid.org/0000-0001-9929-0703)
- Timo Wirth (ORCID: https://orcid.org/0000-0002-0102-4608)
- Luisa Klotz (ORCID: https://orcid.org/0000-0001-5439-9633)
- Anna Maria Hunkemöller (ORCID: https://orcid.org/0000-0002-5021-5697)
- Hermann Pavenstädt (ORCID: https://orcid.org/0000-0001-8717-7770)
- Alexandros Rovas (ORCID: https://orcid.org/0000-0003-3866-0701)
Institutions
- University Hospital Münster (DE)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-05-23
- DOI
- https://doi.org/10.3389/fimmu.2025.1589959
- Primary Topic
- Sepsis Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Deutsche Forschungsgemeinschaft