Baoshentongluo Formula relieves podocyte injury in diabetic kidney disease through regulating mitophagy via PINK1/Parkin signaling pathway
Our integrated in vitro and in vivo findings establish that BSTL protects against DKD progression by selectively inhibiting PINK1/Parkin-dependent mitophagy in podocytes to inhibit podocyte injury, which provides both mechanistic insights and therapeutic potential for clinical DKD management.
Authors
- Jingwen Zhao
- Yanyu Pang
- Yufei Liu (ORCID: https://orcid.org/0000-0002-7570-6978)
- Yutong Wang (ORCID: https://orcid.org/0000-0001-8943-1832)
- Mengdi Wang (ORCID: https://orcid.org/0000-0002-2101-9507)
- Lei Tian (ORCID: https://orcid.org/0000-0002-7216-5352)
- Wenjing Zhao (ORCID: https://orcid.org/0000-0002-3264-5976)
- Yifan Guo (ORCID: https://orcid.org/0009-0008-9281-6440)
Institutions
- Beijing University of Chinese Medicine (CN)
- Capital Medical University (CN)
- Wangjing Hospital of China Academy of Chinese Medical Sciences (CN)
- Beijing Hospital of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Frontiers in Endocrinology
- Published
- 2025-05-23
- DOI
- https://doi.org/10.3389/fendo.2025.1606326
- Citations
- 2
- Primary Topic
- Chronic Kidney Disease and Diabetes
- Type
- article
- Field-Weighted Citation Impact
- 2.86