Pharmacokinetic and pharmacodynamic analyses of nafamostat in ECMO patients: comparing central vein and ECMO machine samples
The PK/PD models developed from samples collected from both the patient and the ECMO circuit indicate significant differences in PD. Given the observed variability and the high risk of bleeding in ECMO patients, a predictive model incorporating these differences and patient-specific variables could significantly improve anticoagulation management.
Authors
- Gaeun Kang (ORCID: https://orcid.org/0000-0001-9841-1139)
- Hang Jea Jang (ORCID: https://orcid.org/0000-0001-7733-4365)
- So Young Jung (ORCID: https://orcid.org/0000-0003-0155-5473)
- Yong Kyun Kim (ORCID: https://orcid.org/0000-0002-7935-6952)
- Dong Hwan Lee (ORCID: https://orcid.org/0000-0002-8681-099X)
- Ji Hoon Jang (ORCID: https://orcid.org/0000-0002-5048-8820)
- Jae Ha Lee (ORCID: https://orcid.org/0000-0003-0932-2826)
- Minyoung Her
Institutions
- Chonnam National University Hospital (KR)
- Inje University Haeundae Paik Hospital (KR)
- Hallym University Sacred Heart Hospital (KR)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-05-23
- DOI
- https://doi.org/10.3389/fphar.2025.1541131
- Citations
- 1
- Primary Topic
- Mechanical Circulatory Support Devices
- Type
- article
- Field-Weighted Citation Impact
- 0.67
Funders
- Clinical Trial Center, China Medical University Hospital
- Chonnam National University