ESCRT III Regulates Lysosomal Perinuclear Clustering by Inhibiting Kinesin 1 Leading to Agnps Cytotoxicity in Human Cells (Adv. Mater. Interfaces 10/2025)
Silver Nanoparticles In article 2400944, Yinbo Peng, Peng Xu, Yong Fang, and co-workers investigate how silver nanoparticles (AgNPs) induce cytotoxicity in human fibroblasts by disrupting lysosomal transport, leading to lysosomal perinuclear clustering (LPC) and subsequent apoptosis. The research highlights the essential roles of Kinesin 1 and ESCRT III in maintaining lysosomal integrity and offers insights for optimizing AgNP therapeutic applications while minimizing adverse effects.
Authors
- Yong Fang (ORCID: https://orcid.org/0009-0005-6591-1248)
- Peng Xu (ORCID: https://orcid.org/0009-0000-3365-3479)
- Ruizhe He (ORCID: https://orcid.org/0000-0001-5355-3889)
- Aiguo Xie (ORCID: https://orcid.org/0000-0002-4791-8340)
- Tiantian Liu (ORCID: https://orcid.org/0000-0001-9377-9938)
- Chao Xing (ORCID: https://orcid.org/0000-0002-1838-0502)
- Yinbo Peng (ORCID: https://orcid.org/0000-0002-4534-2122)
- Wei Ni
Institutions
- Shanghai Jiao Tong University (CN)
- Shanghai Ninth People's Hospital (CN)
- Wuhan National Laboratory for Optoelectronics (CN)
Publication Details
- Journal
- Advanced Materials Interfaces
- Published
- 2025-05-01
- DOI
- https://doi.org/10.1002/admi.202570030
- Primary Topic
- Cellular transport and secretion
- Type
- article
- Field-Weighted Citation Impact
- 0.00