VSIG4 Promotes Tumour‐Associated Macrophage M2 Polarization and Immune Escape in Colorectal Cancer via Fatty Acid Oxidation Pathway
Colorectal cancer cells secrete lactate to upregulate VSIG4 in macrophages via the H3K18la-METTL14-m6A axis. VSIG4 promotes fatty acid oxidation of macrophages and drives its M2-type polarization. These VSIG4-expressing M2 macrophages promote tumour progression and an immunosuppressive microenvironment. Inhibition of VSIG4 expression can synergistically enhance the therapeutic effect of anti-PD-1 antibody.
Authors
- Tianxiao Wang (ORCID: https://orcid.org/0000-0002-2298-435X)
- Jiafeng Liu (ORCID: https://orcid.org/0000-0002-1030-5559)
- Qunyi Li (ORCID: https://orcid.org/0000-0001-5522-1562)
- Zimei Wu (ORCID: https://orcid.org/0000-0001-9777-0674)
- Yuxin Huang (ORCID: https://orcid.org/0009-0009-4167-1226)
- Xinhai Wang (ORCID: https://orcid.org/0000-0002-8999-3517)
- Huijie Qi
- Xiaojin Shi (ORCID: https://orcid.org/0000-0002-1738-2856)
- Jiyifan Li
- Li Chen (ORCID: https://orcid.org/0000-0001-7670-8062)
- Wenxin Zhang (ORCID: https://orcid.org/0009-0003-5113-6151)
- Mingkang Zhong (ORCID: https://orcid.org/0000-0002-1797-0404)
- Lu Chen (ORCID: https://orcid.org/0000-0001-9019-2007)
- Xiang Mao (ORCID: https://orcid.org/0000-0002-1897-2751)
- Huanying Shi
Institutions
- Fudan University (CN)
- Shanghai Xuhui Central Hospital (CN)
- Huashan Hospital (CN)
Publication Details
- Journal
- Clinical and Translational Medicine
- Published
- 2025-05-01
- DOI
- https://doi.org/10.1002/ctm2.70340
- Citations
- 15
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 11.96