Uhrf1 downregulation promotes β‐cell dedifferentiation by decreasing Foxo1 expression in type 2 diabetes

Uhrf1 knockdown promoted H3K27me3 and H3K9me3 and reduced H3K4me3 level in INS-1 cells, resulting in the downregulation of Foxo1 expression, thus promoting β-cell dedifferentiation.

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Publication Details

Journal
Journal of Diabetes Investigation
Published
2025-05-22
DOI
https://doi.org/10.1111/jdi.70082
Primary Topic
Pancreatic function and diabetes
Type
article
Field-Weighted Citation Impact
0.00
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article

Uhrf1 downregulation promotes β‐cell dedifferentiation by decreasing Foxo1 expression in type 2 diabetes

Lanfang Fu, Juyun Zhang, Lin Zhu, Xubiao Meng
1 links
Journal of Diabetes Investigation
Pancreatic function and diabetes
article

Uhrf1 downregulation promotes β‐cell dedifferentiation by decreasing Foxo1 expression in type 2 diabetes

Lanfang Fu, Juyun Zhang, Lin Zhu, Xubiao Meng
article en

Abstract

Uhrf1 knockdown promoted H3K27me3 and H3K9me3 and reduced H3K4me3 level in INS-1 cells, resulting in the downregulation of Foxo1 expression, thus promoting β-cell dedifferentiation.

Journal of Diabetes InvestigationVol. 16(8)
Haikou City People's Hospital (CN)
Good health and well-being
Openalex Percentile: Top 80%
Pancreatic function and diabetes
DOIOpen Access PDFOpenAlex
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Uhrf1 downregulation promotes β‐cell dedifferentiation by decreasing Foxo1 expression in type 2 diabetes — Lanfang Fu, Juyun Zhang, et al. · Journal of Diabetes Investigation (2025) | TGRS Research Map | TGRS