Mechanism of myocardial damage induced by doxorubicin <i>via</i> calumenin-regulated mitochondrial dynamics and the calcium–Cx43 pathway
Increased cytoplasmic free calcium ion concentration induces calcium overload in ventricular myocytes, leading to decreased Cx43 protein, slowed conduction in myocytes, and increased conduction dispersion, resulting in arrhythmias.
Authors
- Jiayue Cui (ORCID: https://orcid.org/0000-0002-1034-9578)
- Jianjun Du (ORCID: https://orcid.org/0000-0001-7777-079X)
- Sun Yang (ORCID: https://orcid.org/0000-0002-8463-7468)
- Hao Liu (ORCID: https://orcid.org/0000-0001-5293-1024)
- He Zhihui
- Lingyu Bai
- He Shi (ORCID: https://orcid.org/0009-0002-0001-3293)
- Zhe Wu (ORCID: https://orcid.org/0000-0002-1611-8228)
- Ming Zhao
Institutions
- Inner Mongolia University for Nationalities (CN)
- Beihua University (CN)
- Inner Mongolia University (CN)
- Tongliao Academy of Agricultural Sciences (CN)
- Inner Mongolia Autonomous Region Meteorological Bureau (CN)
- Inner Mongolia People's Hospital (CN)
- Jilin Medical University (CN)
- Inner Mongolia Autonomous Region Hospital of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- World Journal of Cardiology
- Published
- 2025-05-23
- DOI
- https://doi.org/10.4330/wjc.v17.i5.104839
- Citations
- 1
- Primary Topic
- ATP Synthase and ATPases Research
- Type
- article
- Field-Weighted Citation Impact
- 0.81