Adjustment of low-dose ATG exposure improves outcomes in allogeneic hematopoietic stem cell transplantation: a prospective multicenter study
Early administration of reduced-dose ATG prevents the incidence of GVHD; furthermore, it potentially optimizes immune reconstitution by lowering post-transplant ATG exposure. The strong correlation between pre-ATG ALC and ATG exposure indicates that ALC-based dosing strategies may be beneficial even in low-dose settings. The ATG/ALC ratio is a practical tool for individualizing ATG dosing during early administration.
Authors
- Hitoshi Kiyoi (ORCID: https://orcid.org/0000-0001-6382-9498)
- Toshimitsu Ueki
- Takahiko Sato (ORCID: https://orcid.org/0000-0002-7553-167X)
- Makoto Murata (ORCID: https://orcid.org/0000-0001-5488-4364)
- Seitaro Terakura (ORCID: https://orcid.org/0000-0002-1194-8046)
- Shingo Kurahashi
- Tetsuya Nishida
- Hirofumi Yokota (ORCID: https://orcid.org/0009-0005-8979-5181)
- Kanae Imai (ORCID: https://orcid.org/0009-0001-1558-4040)
- Yuichiro Inagaki (ORCID: https://orcid.org/0000-0003-4011-8487)
- Shihomi Kuwano
- Ryo Hanajiri (ORCID: https://orcid.org/0000-0002-6034-7909)
- Yuki Takeuchi (ORCID: https://orcid.org/0000-0002-8480-5206)
- Nobuhiko Imahashi (ORCID: https://orcid.org/0000-0002-1398-2002)
- Shiho Hirano
- Toshiyasu Sakai (ORCID: https://orcid.org/0000-0002-3530-7817)
- Masashi Sawa
- Yukiyasu Ozawa
Institutions
- Nagoya University Hospital (JP)
- Japanese Red Cross Nagoya Daiichi Hospital (JP)
- Nagano Red Cross Hospital (JP)
- Anjo Kosei Hospital (JP)
- Toyohashi Municipal Hospital (JP)
- Nagoya Medical Center (JP)
- Nagoya University (JP)
Publication Details
- Journal
- Cytotherapy
- Published
- 2025-05-23
- DOI
- https://doi.org/10.1016/j.jcyt.2025.05.009
- Citations
- 1
- Primary Topic
- Hematopoietic Stem Cell Transplantation
- Type
- article
- Field-Weighted Citation Impact
- 1.77
Funders
- Japan Agency for Medical Research and Development
- Japan Society for the Promotion of Science