A cross‐tissue transcriptome‐wide association study identifies novel susceptibility genes for atrial fibrillation
This cross-tissue TWAS identified five novel AF susceptibility genes (CAMK2D, SPAST2L, CEP68, FKBP7, and SHRMOO3). Elevated expression of FKBP7, CEP68, and CAMK2D increases AF risk, while SPATS2L showed a protective effect, with colocalization analysis implicating CEP68 and SPATS2L as prioritized candidates. The integration of multi-omics approaches effectively unravels AF's genetic mechanisms.
Authors
- Zhaoyu Ren
- Yalin Yuan (ORCID: https://orcid.org/0000-0002-6719-2567)
- Wenjing Zhang (ORCID: https://orcid.org/0000-0001-7964-6792)
- Bin Liang (ORCID: https://orcid.org/0000-0001-9685-9765)
- Xin Zheng (ORCID: https://orcid.org/0000-0003-1384-6999)
Institutions
- Shanxi Medical University (CN)
- Second Hospital of Shanxi Medical University (CN)
Publication Details
- Journal
- Journal of Arrhythmia
- Published
- 2025-05-22
- DOI
- https://doi.org/10.1002/joa3.70097
- Citations
- 3
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 5.45
Funders
- National Natural Science Foundation of China
- Shanxi Medical University