Visible-light-mediated synthesis of 2-sulfenylated pyrrolo[1,2-α]quinoxalines <i>via</i> isocyanide/disulfide radical cascades
We have developed a visible-light-driven photocatalytic tandem reaction system to achieve the efficient synthesis of 2-sulfenylated pyrrolo[1,2-α]quinoxalines based on a radical addition-cyclization mechanism. Mechanistic studies show that the sulfur radical intermediates generated in the reaction system directly participate in the subsequent formation of C-S bonds. This strategy has opened up an efficient synthetic pathway for the precise synthesis of C2-sulfur-substituted heterocyclic compounds.
Authors
- Pei‐Qing Zheng
- Songzhi Kong
- Xia Luo (ORCID: https://orcid.org/0000-0002-1179-880X)
- Haisheng Xie (ORCID: https://orcid.org/0000-0002-2206-7893)
- Xiai Luo (ORCID: https://orcid.org/0000-0002-8094-3118)
- Mengqiang Wu (ORCID: https://orcid.org/0000-0002-0624-4335)
- Chen Chen (ORCID: https://orcid.org/0000-0003-2104-534X)
- yazi Deng
Institutions
- Hunan University of Traditional Chinese Medicine (CN)
- Guangdong Ocean University (CN)
Publication Details
- Journal
- Organic & Biomolecular Chemistry
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5ob00451a
- Citations
- 2
- Primary Topic
- Sulfur-Based Synthesis Techniques
- Type
- article
- Field-Weighted Citation Impact
- 1.87
Funders
- Guangdong Ocean University