Atypical spindle cell/pleomorphic lipomatous tumour: a clinicopathologic, immunohistochemical and molecular study of 55 cases, highlighting <i>TP53</i> gene alterations as a genetic hallmark of atypical pleomorphic lipomatous tumour
APLTs predominantly harbour a TP53 alteration in contrast to ASLT cases. Our findings support the classification of APLT as a distinct (sub)entity within a spectrum that overlaps with ASLT, and it remains to be determined whether the broader term 'ASPLT' will hold up. Furthermore, p53 immunostaining proved to be a potentially valuable diagnostic tool, aiding pathologists in differentiating between ASLT and APLT.
Authors
- Uta Flucke (ORCID: https://orcid.org/0000-0003-0315-4307)
- Thomas Mentzel (ORCID: https://orcid.org/0000-0002-1227-2578)
- Fleur Cordier (ORCID: https://orcid.org/0000-0003-0876-3398)
- Tony G. Kleijn (ORCID: https://orcid.org/0000-0001-5436-8765)
- Siebe Loontiens (ORCID: https://orcid.org/0000-0002-4602-4580)
- Joni Van der Meulen (ORCID: https://orcid.org/0000-0002-1916-2769)
- Jo Van Dorpe (ORCID: https://orcid.org/0000-0001-8175-2930)
- Sarah Van Belle
- Liesbeth Ferdinande (ORCID: https://orcid.org/0009-0008-4030-761X)
- Arjen H.G. Cleven (ORCID: https://orcid.org/0000-0002-3672-4348)
- Joost van Gorp
- David Creytens (ORCID: https://orcid.org/0000-0002-6064-1673)
Institutions
- University Medical Center Groningen (NL)
- Radboud University Nijmegen (NL)
- University of Groningen (NL)
- ZF Friedrichshafen (Germany) (DE)
- Ghent University Hospital (BE)
- Research Foundation - Flanders (BE)
- Radboud University Medical Center (NL)
- Ghent University (BE)
- St. Antonius Ziekenhuis (NL)
- Cancer Research Institute Ghent (BE)
- Amsterdam University Medical Centers (NL)
Publication Details
- Journal
- Histopathology
- Published
- 2025-05-23
- DOI
- https://doi.org/10.1111/his.15474
- Citations
- 2
- Primary Topic
- Sarcoma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 3.04
Funders
- Fonds Wetenschappelijk Onderzoek
- Vlaamse regering