Gold-Catalyzed Conia-Ene Cyclization/Aza-Michael Addition Cascades: Access to Indolinylazepinone PNPs with Anticancer Activity
A modular and streamlined assembly of diverse indolinylazepinone pseudonatural products (PNPs) has been established through post-Ugi gold-catalyzed Conia-ene cyclization/aza-Michael addition cascades. Mechanistic studies revealed that cationic gold acts as a unique soft Lewis acid to furnish this protocol through double activation. This approach facilitates chemo- and regioselective access to target PNPs in moderate to good yields with remarkable anticancer activity.
Authors
- Jinjie Wang (ORCID: https://orcid.org/0000-0002-2046-5716)
- Yue Wei (ORCID: https://orcid.org/0000-0002-1673-2826)
- Shenyou Nie (ORCID: https://orcid.org/0000-0002-7396-8114)
- Yao Chen (ORCID: https://orcid.org/0000-0003-0924-8945)
- Yi He (ORCID: https://orcid.org/0000-0001-8722-7213)
- Dan Ni (ORCID: https://orcid.org/0000-0002-8893-0282)
- Ling Xu (ORCID: https://orcid.org/0000-0002-5801-0733)
- Peirui Zhao
Institutions
- Target (United States) (US)
- Chongqing Medical University (CN)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2025-05-23
- DOI
- https://doi.org/10.1021/acs.joc.5c00625
- Citations
- 1
- Primary Topic
- Catalytic Alkyne Reactions
- Type
- article
- Field-Weighted Citation Impact
- 0.94
Funders
- Chongqing Science and Technology Commission
- Chongqing Municipal Education Commission
- Venture and Innovation Support Program for Chongqing Overseas Returnees