Cu(<scp>OTf</scp>)<sub>2</sub> Catalyzed the Reaction of Donor‐Acceptor Cyclopropanes With Salicylaldehyde Phenylhydrazones: Synthesis Polycyclic Tetrahydropyridazines
ABSTRACT A simple method has been developed to prepare tetrahydro‐5H‐chromeno[4,3‐ c ]pyridazin‐5‐ones by reacting donor‐acceptor cyclopropane 1,1‐dieters with salicylaldehyde phenylhydrazones in the presence of Cu(OTf) 2 , yielding moderate results with excellent diastereoselectivity. Moreover, control experiments revealed that the reaction proceeds via a tandem [3 + 3]‐annulation/lactonization mechanism.
Authors
- Yanmin Huang
- Xiang‐Ying Tang (ORCID: https://orcid.org/0000-0003-3959-3715)
- Jie Pang (ORCID: https://orcid.org/0000-0002-7061-5233)
- Zhiping Liu (ORCID: https://orcid.org/0009-0006-6864-2685)
- Lijie Che
- Jianguo Cui (ORCID: https://orcid.org/0000-0002-1308-6726)
- Chunfang Gan (ORCID: https://orcid.org/0000-0002-1101-6572)
- Jun‐An Xiao
Institutions
- Nanning Normal University (CN)
Publication Details
- Journal
- Journal of Heterocyclic Chemistry
- Published
- 2025-05-01
- DOI
- https://doi.org/10.1002/jhet.4952
- Citations
- 1
- Primary Topic
- Cyclopropane Reaction Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.94
Funders
- Natural Science Foundation of Guangxi Zhuang Autonomous Region