Doxorubicin carrier based on an HCOF platform for potent cancer therapy
Doxorubicin is widely used in cancer treatment, and an effective drug carrier is usually needed to overcome its serious side effects. In this study, a highly monodisperse hollow covalent organic framework (HCOF) was prepared using a two-step method, and then was loaded with DOX with a high loading efficiency of 41.2 wt%. <i>In vivo</i> studies demonstrated excellent antitumor efficacy.
Authors
- Tommy Jiang (ORCID: https://orcid.org/0000-0002-1199-0615)
- Jian Qiao (ORCID: https://orcid.org/0000-0002-5228-2906)
- Jian Zhen Ou (ORCID: https://orcid.org/0000-0002-6971-2634)
- Xiaoying Wei (ORCID: https://orcid.org/0000-0001-5665-209X)
- Luwen Zhang (ORCID: https://orcid.org/0000-0002-8876-3947)
- Meng Liu (ORCID: https://orcid.org/0000-0001-9920-5599)
- Yan Wang (ORCID: https://orcid.org/0000-0003-2057-0097)
- Wenjing Wei
- Maolin Pang (ORCID: https://orcid.org/0000-0001-5125-4615)
Institutions
- Guangxi Normal University (CN)
Publication Details
- Journal
- Dalton Transactions
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5dt00486a
- Citations
- 2
- Primary Topic
- Nanoplatforms for cancer theranostics
- Type
- article
- Field-Weighted Citation Impact
- 1.35
Funders
- National Natural Science Foundation of China
- Specific Research Project of Guangxi for Research Bases and Talents