Dysregulation of Monounsaturated Fatty Acids is Related to α‐Synuclein in Multiple System Atrophy
These findings suggest a prevalence of MUFA dysregulation in specific regions of MSA brain, resulting in MUFA levels remaining high despite decreases in SCD expression. Our study has provided new insights into an unrecognized pathway in MSA and opened a new area of research for better understanding MSA pathogenesis. © 2025 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
Authors
- Nicolas Dzamko (ORCID: https://orcid.org/0000-0002-9121-0294)
- Yue Yang (ORCID: https://orcid.org/0009-0005-3151-3153)
- YuHong Fu (ORCID: https://orcid.org/0000-0003-4539-2039)
- Woojin Scott Kim (ORCID: https://orcid.org/0000-0002-4707-933X)
- Russell Pickford (ORCID: https://orcid.org/0000-0001-8982-7618)
- Glenda Margaret Halliday (ORCID: https://orcid.org/0000-0003-0422-8398)
- Simon J.G. Lewis (ORCID: https://orcid.org/0000-0002-4093-7071)
- Qi Cheng (ORCID: https://orcid.org/0009-0005-4177-2634)
- Finula I. Isik (ORCID: https://orcid.org/0000-0003-2060-1180)
Institutions
- The University of Sydney (AU)
- UNSW Sydney (AU)
- People's Liberation Army 411 Hospital (CN)
- Macquarie University (AU)
Publication Details
- Journal
- Movement Disorders
- Published
- 2025-05-23
- DOI
- https://doi.org/10.1002/mds.30248
- Citations
- 4
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 5.56
Funders
- Neuroscience Research Australia
- University of New South Wales
- University of Sydney
- National Institutes of Health
- Medical Research Council
- National Health and Medical Research Council