Neurolymphomatosis: The Sinister Face of Lymphoma

Neurolymphomatosis (NL) is a rare clinical condition characterized by the infiltration of malignant lymphocytes into the cranial or peripheral nerves, nerve roots, or plexus. Diagnosis can be clinically challenging due to its variable presentation. It usually occurs in B cell lymphoma; however, a few cases of extranodal killer/T cell lymphoma. Most cases present at a secondary site in patients with primary site in remission. ¹⁸Fluorine fluorodeoxyglucose positron emission tomography/computed tomography plays an important role in the early detection of NL, resulting in timely treatment. We present a case of a 24-year-old male with nasal natural killer T cell lymphoma who initially responded to treatment but relapsed with NL based on clinical and radiological findings.