Antibodies against <i>Clostridium butyricum</i> in the children of mothers at risk for gestational diabetes

Gestational diabetes mellitus (GDM) is linked to an imbalance in gut microbiota composition, which can be transferred to the mother's offspring. <i>Clostridium butyricum</i>, known for its health benefits in diabetes and allergy, lacks sufficient data regarding its effect on the immune system's development in the offspring of mothers with GDM. This study assessed antibody responses against <i>C. butyricum</i> T2F3 in children of mothers at risk for GDM, involving 88 children aged 1-6 years. Antibody responses were measured with flow cytometry and immunoblot. Lower IgG median fluorescence intensity (MFI) values and fewer IgA and IgG bands against <i>C. butyricum</i> were detected in children of mothers with GDM. Maternal body mass index was positively associated with children's IgG MFI and number of IgG bands. Fewer IgA bands were detected in children with higher IgE levels, atopic dermatitis, asthma, and allergic rhinitis. More IgG bands were detected in children with higher anti-β-lactoglobulin IgG levels. Children with autoimmune risk-related HLA-DR3/DQ2.5 had fewer IgA bands, while those with neutral HLA-DR1/DQ5 had higher IgA, but lower IgG MFI. These results indicate that maternal prenatal changes could affect their offspring's immune response against <i>C. butyricum</i>. Moreover, <i>C. butyricum</i> could have a protective role against allergic sensitization.

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Publication Details

Journal
Immunological Medicine
Published
2025-05-23
DOI
https://doi.org/10.1080/25785826.2025.2504021
Primary Topic
Gestational Diabetes Research and Management
Type
article
Field-Weighted Citation Impact
0.00

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article

Antibodies against Clostridium butyricum in the children of mothers at risk for gestational diabetes

Mikael Knip, Aki Sinkkonen, Ija Talja, Daniel Agardh et al.
Immunological Medicine
Gestational Diabetes Research and Management
article

Antibodies against Clostridium butyricum in the children of mothers at risk for gestational diabetes

Mikael Knip, Aki Sinkkonen, Ija Talja, Daniel Agardh, Susanne Petri, Nigi Laura, Anne Kirss, Puustinen Leena, Helis Janson, Molinier Matthieu, Ullah Ubaid, B Alexander, Bisgaard Hans, Aili Tagoma, Elena Brutskaya-Stempkovskaya, Virtanen Suvi, Timothy H. Rainer, Jorma Toppari, Kristi Alnek, K Starace Anne, Kiviranta Hannu, JM Sini, Uibo Raivo, Mäkelä Iida, R Panu, Suat Fazıl Akı, Martin Romantschuk, Y K Cheung Peter, Stokholm Jakob, L Keiski Riitta, Sevelsted Astrid, Celeste Peterson, Sami Oikarinen, Hakola Leena, Matti Nykter, Miguel Angel María María, Eva Froňková, Marja I. Roslund, Francesco Dotta, S Jermiin Lars, Raivo Uibo, Graciela Gómez Silva, Aronsson Carin Andrén, Laura Solerte, Siiri Kõljalg, Tamara Vorobjova, German Tapia, R T Palmroth Marja, Lehtonen Jussi, Thorsen Jonathan, Gabriele Bellenberg, Abram Alar, R. Chavan Edith, Chai-Gao Hui, Cristina Di Stefano, Meriam Johannes, Sandrine Daniel, Hyöty Heikki, Kurppa Kalle, Anu Bärenson, Petrosino Joseph, Veijola Riitta, C Peter, E Laura, L María, Sebastiani Guido, Maillet Robert, E Nidecker Anna, Papadopoulou Korina, Bønnelykke Klaus, Brandt Sarah, Laiho Jutta, Laitinen Olli, Lindfors Katri, Numminen Henna, Nurminen Noora, Saarinen Niila, Sioofy-Khojine Amirbabak, Viiri Keijo, Lundgren Markus, Lund-Blix Nicolai, Rantala Aino-Kaisa, Størdal Ketil, Lempainen Johanna, Rasool Omid, Suomi Tomi, Peet Aleksandr, Simre Kärt, Tillmann Vallo, Cinek Ondrej, Havlik Jaroslav, Barannik Emilia, Nevanen Tarja, Pajula Juha, Parmes Eija, Pärkkä Juha, Ranta Jukka, Rökman Jyri, Bärenson Anu, Laidmäe Ivo, Tagoma Aili, Vorobjova Tamara, Burr Loïc, Paoletti Samantha, Wicaksono Wisnu, Hoffman Kristi, Salo Rosanna, Häme Lauri, Karabatea Apostolia
article en

Abstract

Gestational diabetes mellitus (GDM) is linked to an imbalance in gut microbiota composition, which can be transferred to the mother's offspring. <i>Clostridium butyricum</i>, known for its health benefits in diabetes and allergy, lacks sufficient data regarding its effect on the immune system's development in the offspring of mothers with GDM. This study assessed antibody responses against <i>C. butyricum</i> T2F3 in children of mothers at risk for GDM, involving 88 children aged 1-6 years. Antibody responses were measured with flow cytometry and immunoblot. Lower IgG median fluorescence intensity (MFI) values and fewer IgA and IgG bands against <i>C. butyricum</i> were detected in children of mothers with GDM. Maternal body mass index was positively associated with children's IgG MFI and number of IgG bands. Fewer IgA bands were detected in children with higher IgE levels, atopic dermatitis, asthma, and allergic rhinitis. More IgG bands were detected in children with higher anti-β-lactoglobulin IgG levels. Children with autoimmune risk-related HLA-DR3/DQ2.5 had fewer IgA bands, while those with neutral HLA-DR1/DQ5 had higher IgA, but lower IgG MFI. These results indicate that maternal prenatal changes could affect their offspring's immune response against <i>C. butyricum</i>. Moreover, <i>C. butyricum</i> could have a protective role against allergic sensitization.

Immunological MedicineVol. 48(4)
Tartu University Hospital (EE), Natural Resources Institute Finland (FI), University of Tartu (EE)
Eesti Teadusagentuur
Zero hunger
Openalex Percentile: Top 85%
Gestational Diabetes Research and Management
DOIOpen Access PDFOpenAlex
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