Genetic History of Ancient Xinjiang Revealed by Ancient DNA Study: A Hub of Eurasian Population Migration and Cultural Exchange

Xinjiang, a “genetic crossroads” of Eurasia, offers critical insights into transcontinental population migrations, cultural exchanges, and genetic fusion. This review synthesizes ancient genomic data from about 200 individuals (from the Bronze Age to the Historical Era), alongside archaeological, paleo microbial, and environmental evidence. Key findings include: (1) Bronze Age genetic heterogeneity: Tarim Basin populations (e.g., Xiaohe culture) retained high Ancient North Eurasian (ANE) ancestry, while northern Xinjiang groups exhibited tripartite admixture among ANE, Afanasievo pastoralists, and Baikal hunter-gatherers; (2) Stratified admixture patterns emerged during the Iron Age to Historical Era, shaped by Xinjiang’s “barrier-and-connection” geography traits; (3) Trans-Eurasian interactions were propelled by technological diffusion (e.g., metallurgy), socio-political transformations (e.g., Silk Road governance), and adaptive strategies (e.g., lactose fermentation), positioning Xinjiang as a nexus of Eurasian mutil-connectivity. Our synthesis bridges genetics, archaeology, and environmental clues, highlighting Xinjiang’s critical role in Eurasian population dynamics. Future research should employ high-resolution spatiotemporal sampling and interdisciplinary approaches to unravel genetic-societal coupling during vital historical phases (e.g., Xiongnu expansion) and molecular mechanisms of environmental adaptation.