Cardiac Sympathetic Denervation Mitigated Ischemic Cardiomyopathy Progression in a Rat Model of Sleep Apnea
Our data demonstrate that CSD prevents IH-induced sympathetic hyperactivity, depletion of cardiac adrenergic reserve, and deterioration of cardiac function in a rat model of ischemic cardiomyopathy. This study highlights the intricate interplay between sympathetic activity and hypoxia in cardiac regeneration and underscores the importance of managing sympathetic hyperactivity in ischemic cardiomyopathy, particularly in the context of comorbid obstructive sleep apnea.
Authors
- Florent Chuffart (ORCID: https://orcid.org/0000-0001-6064-5183)
- Claire Arnaud (ORCID: https://orcid.org/0000-0003-0964-9423)
- Emeline Lemarié
- Francesca Rochais (ORCID: https://orcid.org/0000-0001-9355-8916)
- Stéphane Doutreleau (ORCID: https://orcid.org/0000-0001-8816-0356)
- Diane Godin‐Ribuot (ORCID: https://orcid.org/0000-0001-7589-932X)
- Côme Pasqualin (ORCID: https://orcid.org/0000-0001-8625-1617)
- Maximin Détrait (ORCID: https://orcid.org/0000-0002-6380-540X)
- Emma Billoir (ORCID: https://orcid.org/0009-0004-0471-0613)
- Jean‐Louis Pépin (ORCID: https://orcid.org/0000-0003-3832-2358)
- Stéphanie Paradis (ORCID: https://orcid.org/0000-0001-8749-6827)
- Guillaume Vial (ORCID: https://orcid.org/0000-0002-7333-8526)
- Jonathan Gaucher (ORCID: https://orcid.org/0000-0002-1654-8009)
- Sophie Bouyon (ORCID: https://orcid.org/0000-0002-7868-1884)
- Fabien Hubert (ORCID: https://orcid.org/0000-0003-1360-4092)
- Elise Belaïdi (ORCID: https://orcid.org/0000-0003-4589-1612)
Institutions
- Université de Tours (FR)
- Centre National de la Recherche Scientifique (FR)
- Inserm (FR)
- Aix-Marseille Université (FR)
- Centre Hospitalier Universitaire de Grenoble (FR)
- Institut pour l'avancée des biosciences (FR)
- Université Grenoble Alpes (FR)
Publication Details
- Journal
- Journal of the American Heart Association
- Published
- 2025-05-23
- DOI
- https://doi.org/10.1161/jaha.124.038781
- Citations
- 1
- Primary Topic
- Obstructive Sleep Apnea Research
- Type
- article
- Field-Weighted Citation Impact
- 1.16