Advances in the Study of Ferroptosis in Neurovascular Diseases and Its Correlation with Moyamoya Disease

神经血管疾病是指一系列由于脑血管结构或功能异常引起的疾病，极大地威胁人类的身体健康。烟雾病是一种慢性，进行性狭窄神经血管疾病。目前烟雾病的发病原因及其机制并不明确。铁死亡是一种铁依赖性、脂质过氧化驱动的新型的调控性细胞死亡方式，本文通过总结目前对铁死亡与神经血管疾病的研究进展，探讨了铁死亡在神经血管疾病中发挥的作用，分析了烟雾病与铁死亡之间的联系。Neurovascular diseases are a series of disorders caused by structural or functional abnormalities with the cerebral blood vessels, which greatly threaten human health. Moyamoya disease is a chronic, progressive stenotic neurovascular disease. The pathogenesis of moyamoya disease and its mechanisms are not clear at present. Ferroptosis is a novel iron-dependent, lipid peroxidation-driven regulated cell death. In this paper, we summarize the current research progress on ferroptosis and neurovascular diseases, discuss the role played by iron death in neurovascular diseases, and analyze the link between moyamoya disease and ferroptosis.