Research Progress of Kidney Injury after Hematopoietic Stem Cell Transplantation in Children

近年来，随着医学界对造血干细胞移植(hematopoietic stem cell trans-plantation, HSCT)的研究不断加深，这种治疗方法的适应证也在不断扩大，越来越多的非肿瘤性疾病，如再生障碍性贫血、免疫缺陷和先天代谢紊乱也可以通过HSCT得到有效的治疗。化疗药物相关的肾毒性、移植物抗宿主病(GVHD)、和感染等因素，使患儿在接受造血干细胞移植后发生肾损伤的风险大大增加。而目前对于这种移植后短期或长期肾脏功能损害的研究并不完备。本文就移植后肾损伤的类型、相关危险因素以及目前的诊疗进展进行综述，期望能够对HSCT相关肾损伤的研究提供进一步的研究思路。In recent years, as research on hematopoietic stem cell transplantation (HSCT) has deepened within the medical community, the indications for this treatment method have expanded. Non-neoplastic diseases such as aplastic anemia, immune deficiency, and congenital metabolic disorders can now be effectively treated by HSCT. However, chemotherapy drug-related nephrotoxicity, graft-versus-host disease (GVHD), and infection increase the risk of kidney injury after HSCT. Currently, our understanding of short-term or long-term renal function impairment after transplantation is incomplete. This article reviews the types of renal injury related to HSCT, explores associated risk factors and discusses current progress in diagnosis and treatment. It aims to provide further research ideas for studying HSCT-related renal injury.