Hochuekkito accelerates recovery from cisplatin induced-muscle atrophy accompanied by slow-twitch fiber-specific microRNA upregulation in mice
HET increased locomotor activity and muscle weight in cisplatin-induced muscle atrophy model mice, probably by enhancing myogenesis in slow-twitch fibers, which was related to miRNA expression changes. Thus, HET may be useful in treating cisplatin-induced muscle atrophy.
Authors
- Shunsuke Ohnishi (ORCID: https://orcid.org/0000-0003-1194-4149)
- Hitomi Sekine
- Sachiko Mogami (ORCID: https://orcid.org/0000-0001-7914-4928)
- Chinami Matsumoto (ORCID: https://orcid.org/0009-0003-4208-6463)
- Naoki Fujitsuka (ORCID: https://orcid.org/0000-0003-0856-5850)
- Hiroshi Takeda (ORCID: https://orcid.org/0000-0001-7672-4687)
Institutions
- Hokkaido University (JP)
- Hokkaido Pharmaceutical University (JP)
- Tsumura Research Institute (Japan) (JP)
- Hokkaido Orthopedic Surgery Memorial Hospital (JP)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-05-15
- DOI
- https://doi.org/10.3389/fphar.2025.1502563
- Citations
- 1
- Primary Topic
- Cancer Treatment and Pharmacology
- Type
- article
- Field-Weighted Citation Impact
- 1.05
Funders
- Tsumura and Company