Yogurt in Combination with Inactivated Pediococcus lactis Modulated Feline Lipid Metabolism, Anti-Inflammation and Fecal Microbiota

Yogurt and postbiotics are both beneficial for intestinal health of pets. This study was conducted to investigate the effects of yogurt with postbiotics in cats. A total of 18 adult cats were randomly divided into three groups, CK group (Control <i>n</i> = 6, free feeding and drinking without any probiotic products), Y group (Yogurt, <i>n</i> = 6, 50 g/day), and YP group (Yogurt + 2% postbiotics, 50 g/day), with the same environment and diet. On the 21st day, blood and fecal samples were collected and tested for biochemical indices, immunological parameters, inflammatory factors, and fecal flora, respectively. The results showed that feeding postbiotic yogurt to cats significantly reduced the levels of total bilirubin (TBIL), total bile acids (TBA), triglycerides (TG), glucose (GLU), urea nitrogen (BUN), creatinine (CREA), tumor necrosis factor-alpha (TNF-α), and Interleukin-6 (IL-6) (<i>p</i> < 0.05), and significantly increased Immunoglobulin A (sIgA) (<i>p</i> < 0.05) compared to the CK group. The abundance of <i>Bifidobacterium</i> in YP group was elevated, the Shannon violin plots showed that the intestinal flora of the YP group was less dispersed. Notably <i>Enterococcaceae</i> and <i>Enterococcus</i> were significantly elevated in the Y group (<i>p</i> < 0.05) and <i>Streptococcus salivarius</i> subsp. <i>thermophilus</i> in the YP group (<i>p</i> < 0.05). Therefore, this study suggests that yogurt with postbiotic is a good choice for improving intestinal health and immune function in cats and possesses good research and application prospects.