Alzheimer's Disease Sequencing Project release 4 whole genome sequencing dataset
We detailed the genetic architecture and quality of the Alzheimer's Disease Sequencing Project release 4 whole genome sequences. We identified 435 million single nucleotide polymorphisms, insertions and deletions, and structural variants from diverse genomes. We harmonized extensive phenotypes, linkage disequilibrium reference panel on subset of samples. Data is publicly available at NIAGADS Data Storage Site, variants and annotations are browsable on two different websites.
Authors
- Wan‐Ping Lee (ORCID: https://orcid.org/0000-0002-5305-1181)
- Živadin Katanić
- Timothy J. Hohman (ORCID: https://orcid.org/0000-0002-3377-7014)
- Arthur W. Toga (ORCID: https://orcid.org/0000-0001-7902-3755)
- Xiaoling Zhang (ORCID: https://orcid.org/0000-0001-8237-1857)
- John Farrell (ORCID: https://orcid.org/0000-0002-8726-5997)
- Otto Valladares (ORCID: https://orcid.org/0000-0001-8055-2187)
- Tamil Iniyan Gunasekaran (ORCID: https://orcid.org/0000-0002-8639-5060)
- Congcong Zhu (ORCID: https://orcid.org/0000-0002-4035-1513)
- Yuk Yee Leung (ORCID: https://orcid.org/0000-0002-3047-5440)
- Li‐San Wang (ORCID: https://orcid.org/0000-0002-3684-0031)
- Lindsay A. Farrer (ORCID: https://orcid.org/0000-0001-5533-4225)
- Michael L. Cuccaro (ORCID: https://orcid.org/0000-0003-4769-0785)
- Prabhakaran Gangadharan
- Yumi Jin (ORCID: https://orcid.org/0000-0003-2499-8760)
- Adam C. Naj (ORCID: https://orcid.org/0000-0002-9621-2942)
- Po‐Liang Cheng (ORCID: https://orcid.org/0009-0007-0046-0313)
- Lauren Bass
- William S. Bush (ORCID: https://orcid.org/0000-0002-9729-6519)
- Nicholas R. Wheeler (ORCID: https://orcid.org/0000-0003-2248-8919)
- Pedro Mena (ORCID: https://orcid.org/0000-0003-2150-2977)
- Taha Iqbal
- Richard P Mayeux (ORCID: https://orcid.org/0000-0001-6519-9696)
- Luke Carter
- Laura B. Cantwell
- F. S. Turner (ORCID: https://orcid.org/0000-0002-7935-7621)
- Eden R. Martin (ORCID: https://orcid.org/0000-0002-4035-9152)
- Brian W. Kunkle (ORCID: https://orcid.org/0000-0002-9515-5157)
- Emily Greenfest‐Allen (ORCID: https://orcid.org/0000-0002-7294-8461)
- Badri Narayan Vardarajan (ORCID: https://orcid.org/0000-0002-5560-4085)
- Heather Nicaretta
- Hui Wang (ORCID: https://orcid.org/0000-0003-4043-5060)
- Yi Zhao (ORCID: https://orcid.org/0000-0003-4766-5934)
- Heather White
- Margaret A. Pericak‐Vance
- Pavel P. Kuksa
- Amanda Kuzma
- Liming Qu
- Clifton L. Dalgard
- Gerard D. Schellenberg
- Youli Ren
- Maureen Kirsch
- Jonathan L. Haines
- Naveen Saravanan
Institutions
- Boston University (US)
- University of Southern California (US)
- University of Miami (US)
- Uniformed Services University of the Health Sciences (US)
- Columbia University Irving Medical Center (US)
- Case Western Reserve University (US)
- Columbia University (US)
- University of Pennsylvania (US)
- Vanderbilt University Medical Center (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-05-01
- DOI
- https://doi.org/10.1002/alz.70237
- Citations
- 14
- Primary Topic
- Genomics and Rare Diseases
- Type
- article
- Field-Weighted Citation Impact
- 25.44
Funders
- U.S. Department of Health and Human Services
- Mayo Clinic
- Alzheimer's Association
- Alzheimer's Drug Discovery Foundation
- Eli Lilly and Company
- Merck
- Biogen
- University of Southern California
- AbbVie
- University of Miami
- University of Pennsylvania
- Arizona Department of Health Services
- Alzheimer's Disease Neuroimaging Initiative
- BioClinica
- Baylor College of Medicine
- Case Western Reserve University
- Novartis Pharmaceuticals Corporation
- Takeda Pharmaceutical Company
- CurePSP
- Northern California Institute for Research and Education
- Ministry of Education
- Wellcome Trust
- EU Joint Programme – Neurodegenerative Disease Research
- Fujirebio US
- GHR Foundation
- Rainwater Charitable Foundation
- Framingham Heart Study
- European Commission
- Austrian Science Fund
- Erasmus Medisch Centrum
- Oesterreichische Nationalbank
- Deutsches Zentrum für Neurodegenerative Erkrankungen
- Medizinische Universität Graz
- H. Lundbeck A/S
- Victorian Brain Bank
- National Institutes of Health
- Genentech
- GE Healthcare
- Uniformed Services University of the Health Sciences
- Tau Consortium
- Canadian Institutes of Health Research
- Medical Research Council
- European Research Council
- National Institute on Aging
- National Heart, Lung, and Blood Institute
- National Human Genome Research Institute
- National Institute of Neurological Disorders and Stroke
- National Institute of Biomedical Imaging and Bioengineering