Psychosocial behavioral phenotypes of racially/ethnically minoritized older adults enrolled in HABS‐HD differ on neuroimaging measures of brain age gap, hippocampal volume, and cortical thickness
Brain age gap (BAG), hippocampal volumes, and cortical thickness differences were tested.The High Resource/Low Distress phenotype had the most favorable imaging outcomes.The Low Resource/High Distress phenotype demonstrated the poorest imaging outcomes.Risk for Alzheimer's disease and related dementias (ADRD) may differ across psychosocial behavioral phenotypes.
Authors
- Meredith N. Braskie (ORCID: https://orcid.org/0000-0002-6439-4243)
- Alexandra J. Weigand (ORCID: https://orcid.org/0000-0002-7931-1383)
- Alexandra L. Clark (ORCID: https://orcid.org/0000-0002-7437-5409)
- Julie K. Wisch (ORCID: https://orcid.org/0000-0003-3624-2784)
- Sid E. O’Bryant (ORCID: https://orcid.org/0000-0003-0582-5266)
- Makenna B. McGill (ORCID: https://orcid.org/0000-0003-4316-7719)
- Kalen J. Petersen (ORCID: https://orcid.org/0000-0002-4864-9648)
- Beau M. Ances (ORCID: https://orcid.org/0000-0003-3862-7397)
- Kelsey R. Thomas (ORCID: https://orcid.org/0000-0003-4277-8876)
Institutions
- University of Southern California (US)
- University of North Texas (US)
- University of North Texas Health Science Center (US)
- University of California, San Francisco (US)
- Washington University in St. Louis (US)
- VA San Diego Healthcare System (US)
- University of California San Diego Medical Center (US)
- Institute of Art History (HU)
- The University of Texas at Austin (US)
Publication Details
- Journal
- Alzheimer s & Dementia Translational Research & Clinical Interventions
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1002/trc2.70109
- Citations
- 1
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 1.47
Funders
- U.S. Department of Veterans Affairs
- Alzheimer's Association
- National Institutes of Health
- National Institute on Aging