Clinical utility of CSF Aβ38 in Japanese research and clinical cohorts
The diagnostic value of cerebrospinal fluid (CSF) amyloid beta (Aβ)38 was examined in Japanese research and clinical cohorts.CSF Aβ42/Aβ38 and Aβ42/Aβ40 showed comparable performance to detect brain Aβ deposition.CSF Aβ42/Aβ38 and Aβ42/Aβ40 discordant group showed a characteristic profile.CSF Aβ38 and Aβ40 were prominently decreased in progressive supranuclear palsy and idiopathic normal pressure hydrocephalus.
Authors
- Tamao Tsukie
- Takanobu Ishiguro (ORCID: https://orcid.org/0000-0002-8205-4912)
- Kensaku Kasuga (ORCID: https://orcid.org/0000-0002-2178-0769)
- Masataka Kikuchi (ORCID: https://orcid.org/0000-0002-9562-841X)
- Takeshi Iwatsubo (ORCID: https://orcid.org/0000-0003-1160-8129)
- Osamu Onodera (ORCID: https://orcid.org/0000-0003-3354-5472)
- Akinori Miyashita (ORCID: https://orcid.org/0000-0003-2508-9649)
Institutions
- Niigata University (JP)
- The University of Tokyo (JP)
Publication Details
- Journal
- Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1002/dad2.70125
- Primary Topic
- Cerebrospinal fluid and hydrocephalus
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Japan Agency for Medical Research and Development
- Ministry of Health, Labour and Welfare
- Japan Society for the Promotion of Science