Dual Role of NRF2 in Pancreatic Precursor Lesions
This study reveals a context-dependent role of NRF2 in pancreatic tumorigenesis, promoting PanIN progression while suppressing IPMN formation. These findings provide new insights into early lesion heterogeneity and highlight NRF2 status as a potential biomarker for risk stratification in pancreatic cancer.
Authors
- Masafumi Nakamura (ORCID: https://orcid.org/0000-0002-6196-8643)
- Lela DeVine (ORCID: https://orcid.org/0000-0001-9809-9501)
- Yoshinao Oda (ORCID: https://orcid.org/0000-0001-9636-1182)
- Shu Ichimiya (ORCID: https://orcid.org/0000-0002-8184-615X)
- Iok In Christine Chio (ORCID: https://orcid.org/0000-0002-3635-2679)
- John P. O'Sullivan
- Sei‐Hyun Ahn
- Takeo Yamamoto
- Mike Dixon
- Alex Chen
Institutions
- Kyushu University (JP)
- Columbia University Irving Medical Center (US)
- Cancer Genetics (United States) (US)
- Columbia University (US)
- Barnard College (US)
Publication Details
- Journal
- Cancer Research Communications
- Published
- 2025-05-23
- DOI
- https://doi.org/10.1158/2767-9764.crc-25-0107
- Primary Topic
- Pancreatic and Hepatic Oncology Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00