S1PR3 inhibition impairs cell cycle checkpoint via the AKT/WEE1 pathway in oral squamous cell carcinoma
These findings reveal a critical role for S1PR3 in regulating OSCC cell cycle via the AKT/WEE1/CDC2 pathway, thus offering a basis for developing treatment strategies for OSCC patients.
Authors
- Fuxiang Chen (ORCID: https://orcid.org/0000-0002-4093-2676)
- Beihui Xu
- Guifang Gan (ORCID: https://orcid.org/0000-0001-5735-3702)
- Jinghao Liu (ORCID: https://orcid.org/0000-0002-5922-1698)
- Xin Zhou (ORCID: https://orcid.org/0000-0002-6566-9018)
- Chen Xu (ORCID: https://orcid.org/0000-0001-5557-7999)
- Xinyu Zhou (ORCID: https://orcid.org/0000-0001-6067-999X)
Institutions
- Shanghai Jiao Tong University (CN)
- Shanghai Ninth People's Hospital (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-05-23
- DOI
- https://doi.org/10.1186/s12967-025-06582-4
- Citations
- 2
- Primary Topic
- PI3K/AKT/mTOR signaling in cancer
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- National Natural Science Foundation of China
- Shanghai Jiao Tong University
- School of Medicine, Shanghai Jiao Tong University
- National Key Research and Development Program of China
- Fundamental Research Funds for the Central Universities