PELI1 silencing delays intervertebral disc degeneration by impeding nucleus pulposus cell death
PELI1 May promote IDD progression by expediting nucleus pulposus cell death and participates in the inflammatory response regulated by the NLRP3 inflammasome in nucleus pulposus cells. These suggest PELI1 as a potential therapeutic target for the treatment of IDD.
Authors
- Xiaodong Wei (ORCID: https://orcid.org/0000-0001-9126-6709)
- Jingjie Wang (ORCID: https://orcid.org/0000-0003-3700-3013)
- Chao Yu (ORCID: https://orcid.org/0000-0002-3744-9413)
Institutions
- Yantaishan Hospital (CN)
Publication Details
- Journal
- Connective Tissue Research
- Published
- 2025-05-23
- DOI
- https://doi.org/10.1080/03008207.2025.2508841
- Citations
- 1
- Primary Topic
- Spine and Intervertebral Disc Pathology
- Type
- article
- Field-Weighted Citation Impact
- 1.47