Transcriptomic insights into the interplay between polyketide biosynthesis and other secondary metabolite biosynthetic clusters and biological pathways in entomopathogen Beauveria bassiana

This study provides the first transcriptomic evidence that the <i>pks15</i> cluster regulates multiple secondary metabolite clusters, including bassianolide, siderophores, tenellin, oosporein, and several unidentified PKS and NRPS clusters. Additionally, <i>pks15</i> is associated with fungal cell wall remodeling and immune evasion. Our work uncovers an expanded regulatory role for PKS15, revealing novel connection between metabolite biosynthesis and virulence-associated processes, and offering opportunities for targets for biocontrol improvement and metabolite engineering.

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Publication Details

Journal
Frontiers in Microbiology
Published
2025-05-23
DOI
https://doi.org/10.3389/fmicb.2025.1583637
Citations
2
Primary Topic
Entomopathogenic Microorganisms in Pest Control
Type
article
Field-Weighted Citation Impact
3.34

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article

Transcriptomic insights into the interplay between polyketide biosynthesis and other secondary metabolite biosynthetic clusters and biological pathways in entomopathogen Beauveria bassiana

Morakot Tanticharoen, Nuchnudda Wichienchote, Chaiwat Naktang, Sithichoke Tangphatsornruang et al.
2 citations
Frontiers in Microbiology
Entomopathogenic Microorganisms in Pest Control
3.34
article

Transcriptomic insights into the interplay between polyketide biosynthesis and other secondary metabolite biosynthetic clusters and biological pathways in entomopathogen Beauveria bassiana

Morakot Tanticharoen, Nuchnudda Wichienchote, Chaiwat Naktang, Sithichoke Tangphatsornruang, Thippawan Yoocha, Alongkorn Amnuaykanjanasin, Phornsiri Pechsrichuang, Wachiraporn Toopaang, Yuliang Yang
article en
2 citations

Abstract

This study provides the first transcriptomic evidence that the <i>pks15</i> cluster regulates multiple secondary metabolite clusters, including bassianolide, siderophores, tenellin, oosporein, and several unidentified PKS and NRPS clusters. Additionally, <i>pks15</i> is associated with fungal cell wall remodeling and immune evasion. Our work uncovers an expanded regulatory role for PKS15, revealing novel connection between metabolite biosynthesis and virulence-associated processes, and offering opportunities for targets for biocontrol improvement and metabolite engineering.

Frontiers in MicrobiologyVol. 16
National Science and Technology Development Agency (TH), National Chung Hsing University (TW), Southern Taiwan Science Park (TW), Agricultural Biotechnology Research Center, Academia Sinica (TW), King Mongkut's University of Technology Thonburi (TH), Academia Sinica (TW), National Center for Genetic Engineering and Biotechnology (TH), National Taipei University (TW)
Academia Sinica, National Science and Technology Council, Arizona Biomedical Research Commission, Agricultural Biotechnology Research Center, Academia Sinica
Openalex Percentile: Top 9%
Entomopathogenic Microorganisms in Pest Control
3.34
DOIOpen Access PDFOpenAlex
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