ITIH4 alleviates OVA-induced asthma by regulating lung-gut microbiota
ITIH4 ameliorates asthma symptoms by modulating lung and gut microbiota, dampening Th2-driven inflammation, and restoring mucosal immune balance. These findings support ITIH4 as a potential candidate for microbiome-targeted asthma therapy.
Authors
- Yi-Hsuan Liu
- Hsiao‐Chi Chuang (ORCID: https://orcid.org/0000-0003-4651-5192)
- Kang-Yun Lee (ORCID: https://orcid.org/0000-0002-1203-4094)
- Kian Fan Chung (ORCID: https://orcid.org/0000-0001-7101-1426)
- Yueh‐Lun Lee (ORCID: https://orcid.org/0000-0002-8667-1408)
- Yu‐Chun Lo (ORCID: https://orcid.org/0000-0002-3595-5291)
- Chia‐Li Han (ORCID: https://orcid.org/0000-0003-4644-5892)
- Shu‐Chuan Ho (ORCID: https://orcid.org/0000-0002-1616-8647)
- Syue-Wei Peng
- Sheng‐Ming Wu (ORCID: https://orcid.org/0000-0003-1746-5771)
- Zhongxing Liao (ORCID: https://orcid.org/0000-0002-2224-9478)
- Cheng‐Wei Lin (ORCID: https://orcid.org/0000-0003-4622-2680)
- Yi-Wen Lin
- Jer-Hwa Chang
- Yu-Syuan Shih
Institutions
- Taipei Medical University-Shuang Ho Hospital (TW)
- Imperial College London (GB)
- Taipei Medical University (TW)
Publication Details
- Journal
- Molecular Medicine
- Published
- 2025-05-23
- DOI
- https://doi.org/10.1186/s10020-025-01270-x
- Citations
- 3
- Primary Topic
- Asthma and respiratory diseases
- Type
- article
- Field-Weighted Citation Impact
- 3.49
Funders
- Ministry of Education, India
- Taipei Medical University
- National Science and Technology Council
- Wan Fang Hospital