In vitro antioxidant effects and in vivo hepatoprotective effects of Osbeckia octandra, Vernonia cinerea and Atalantia ceylanica on a high fat diet induced metabolic dysfunction-associated steatotic liver disease mouse model

Aqueous extracts of O. octandra, V. cinerea, and A. ceylanica are rich in antioxidants and have the ability to suppress HFD-induced weight gain, dyslipidemias, hepatic steatosis, and hepatic inflammation providing solid evidence for their beneficial effects against initiation and progression of MASLD. Among these extracts, O. octandra stands out with the highest antioxidant activity, lowest cytotoxicity, and most promising hepatoprotective effects.