Assessment of nodal staging and risk factors for nodal involvement in gallbladder cancer
Data from this large multicentre study confirmed that the number of positive nodes is the most discriminative prognostic model for nodal staging in gallbladder cancer. OMEGA-NOPPS provides three simple parameters to stratify nodal involvement according to risk. Incidental gallbladder cancer with lymphovascular and perineural infiltration and poorly differentiated tumours, including early T stages, should be considered for further treatment.
Authors
- Ioannis Gkekas (ORCID: https://orcid.org/0000-0002-7382-3636)
- Supreeth Kunnuru
- Bilal Al‐Sarireh
- Christoph Schwarz (ORCID: https://orcid.org/0000-0002-7676-2779)
- Masakazu Yamamoto (ORCID: https://orcid.org/0000-0001-6027-620X)
- Julie Martin
- David Holroyd (ORCID: https://orcid.org/0000-0002-9057-3675)
- Elizabeth Lockie (ORCID: https://orcid.org/0000-0002-5223-5958)
- Arpad Ivanecz (ORCID: https://orcid.org/0000-0002-1617-9709)
- Houssem Ammar (ORCID: https://orcid.org/0000-0002-3903-3454)
- Giedrius Barauskas (ORCID: https://orcid.org/0000-0002-4321-7280)
- Maryam Ahmad
- Marta Gutiérrez‐Valencia (ORCID: https://orcid.org/0000-0002-3229-6614)
- Mathieu D’Hondt (ORCID: https://orcid.org/0000-0001-5542-3017)
- Stanley W. Ashley (ORCID: https://orcid.org/0000-0001-7632-5037)
- László Piros (ORCID: https://orcid.org/0000-0003-4841-220X)
- Voon Meng Leow
- Harsh Kanhere (ORCID: https://orcid.org/0000-0002-0181-6461)
- Tomas Vanagas (ORCID: https://orcid.org/0000-0002-7460-3635)
- Stefan Löb
- Lily V. Saadat
- Alejandro Brañes (ORCID: https://orcid.org/0000-0002-1512-1046)
- Isabel Jaén-Torrejimeno (ORCID: https://orcid.org/0000-0001-6616-4807)
- Malith Nandasena
- Robert Jones (ORCID: https://orcid.org/0000-0003-4833-6905)
- Ashwin Rammohan (ORCID: https://orcid.org/0000-0001-9528-8892)
- Robert Sutcliffe
- Robert J. Young (ORCID: https://orcid.org/0000-0001-7003-3017)
- Óscar Guevara
- Arianeb Mehrabi (ORCID: https://orcid.org/0000-0001-6163-1525)
- Νικόλαος Παραράς (ORCID: https://orcid.org/0000-0003-3824-0969)
- Mohammad Abu Hilal (ORCID: https://orcid.org/0000-0002-3162-4639)
- Ajith K. Siriwardena (ORCID: https://orcid.org/0000-0001-8004-0560)
- Céline De Meyere
- Haluk Morgül (ORCID: https://orcid.org/0000-0001-8789-0277)
- Mert Erkan (ORCID: https://orcid.org/0000-0002-2753-0234)
- Matthew Byrne (ORCID: https://orcid.org/0000-0001-5106-4424)
- Parthi Srinivasan (ORCID: https://orcid.org/0000-0002-3004-1335)
- Eduardo Fernandes (ORCID: https://orcid.org/0000-0003-1960-1001)
- Luca Viganò (ORCID: https://orcid.org/0000-0002-4108-4832)
- Vasilis Kosmoliaptsis (ORCID: https://orcid.org/0000-0001-7298-1387)
- Stijn van Laarhoven (ORCID: https://orcid.org/0000-0002-3579-2533)
- Francesk Mulita (ORCID: https://orcid.org/0000-0001-7198-2628)
- Hasan H. Eker (ORCID: https://orcid.org/0000-0002-9053-0835)
- Ryota Higuchi
- Miguel Ángel Gómez‐Bravo (ORCID: https://orcid.org/0000-0002-5155-3508)
- Katsuhiko Uesaka
- Raaj Praseedom (ORCID: https://orcid.org/0000-0001-9541-6356)
- Elisabeth Lo
- Caman Thieu
- Michail Vailas (ORCID: https://orcid.org/0000-0002-7357-6532)
- Teresa Perra (ORCID: https://orcid.org/0000-0001-7032-1289)
- Malin Sternby Eilard (ORCID: https://orcid.org/0000-0002-5274-7726)
- Lynn Chong (ORCID: https://orcid.org/0000-0002-2595-958X)
- Volkan Adsay (ORCID: https://orcid.org/0000-0002-1308-3701)
- Anthony J. Scholer (ORCID: https://orcid.org/0000-0002-7693-9298)
- Poya Ghorbani (ORCID: https://orcid.org/0000-0003-2102-7168)
- Javier Lendoire
- Hytham K. S. Hamid (ORCID: https://orcid.org/0000-0001-8068-0154)
- Bas Groot Koerkamp (ORCID: https://orcid.org/0000-0003-1917-6973)
- Luke Bradshaw (ORCID: https://orcid.org/0000-0003-0459-7513)
- Nicholas Mowbray (ORCID: https://orcid.org/0000-0001-9931-0145)
- Shishir K. Maithel (ORCID: https://orcid.org/0000-0002-3591-8925)
- M Zivanovic (ORCID: https://orcid.org/0000-0001-8970-0780)
- Navneet Tiwari
- Sanjay Pandanaboyana (ORCID: https://orcid.org/0000-0003-3099-2197)
- Dhiresh Kumar Maharjan (ORCID: https://orcid.org/0000-0001-9212-3179)
- Konstantinos Perivoliotis (ORCID: https://orcid.org/0000-0002-6622-5734)
- Maria del Mar Achalandabaso Boira
- Asif Jah (ORCID: https://orcid.org/0000-0001-5541-1550)
- J. Peter A. Lodge (ORCID: https://orcid.org/0000-0001-8771-4214)
- Mohamed Adam (ORCID: https://orcid.org/0000-0002-6363-4524)
- Ernesto Sparrelid (ORCID: https://orcid.org/0000-0003-0259-8328)
- Eva María Pueyo Périz
- Fabio Ausania (ORCID: https://orcid.org/0000-0001-8891-2546)
- Rahul Gupta (ORCID: https://orcid.org/0000-0001-7461-2083)
- Evangelos Felekouras
- Celia Villodre
- Alberto Porcu (ORCID: https://orcid.org/0000-0001-6307-8938)
- Toshifumi Wakai (ORCID: https://orcid.org/0000-0003-2443-3428)
- Adnan Alseidi (ORCID: https://orcid.org/0000-0002-0365-1955)
- Harry Spiers (ORCID: https://orcid.org/0000-0001-7308-2711)
- Aarathi Vijayashanker (ORCID: https://orcid.org/0000-0003-0850-1101)
- Andrea Laurenzi (ORCID: https://orcid.org/0000-0002-6847-3379)
- Gabriel Saliba
- Alejandro Serrablo (ORCID: https://orcid.org/0000-0002-9762-3612)
- Mike van Dooren (ORCID: https://orcid.org/0000-0001-6826-9629)
- Sudeep Banerjee (ORCID: https://orcid.org/0000-0002-3014-6006)
- Carmen Cutolo
- Emmanouil Giorgakis (ORCID: https://orcid.org/0000-0002-5019-5497)
- Pablo E. Serrano (ORCID: https://orcid.org/0000-0002-3715-6880)
- Fabio Giannone (ORCID: https://orcid.org/0000-0001-5065-6962)
- Ramesh Singh Bhandari (ORCID: https://orcid.org/0000-0002-8287-948X)
- Hilko A. Swank
- Emmanuel Huguet
- Ronald M. van Dam (ORCID: https://orcid.org/0000-0001-8415-5090)
- José Davide (ORCID: https://orcid.org/0000-0003-3174-2456)
- Luis I. Ruffolo (ORCID: https://orcid.org/0000-0001-6002-9559)
- Flavio Milana (ORCID: https://orcid.org/0000-0003-3570-9573)
- Nikolaos Machairas (ORCID: https://orcid.org/0000-0003-3239-3905)
- Florian Primavesi (ORCID: https://orcid.org/0000-0003-2707-6307)
- Felipe León (ORCID: https://orcid.org/0000-0002-6150-5489)
- Johannes Klose (ORCID: https://orcid.org/0000-0002-7289-2891)
- Maria Caceres (ORCID: https://orcid.org/0000-0001-8815-1513)
- Satheesh Iype (ORCID: https://orcid.org/0000-0002-2822-3017)
- Daniel Hughes
- June S. Peng (ORCID: https://orcid.org/0000-0002-1891-4199)
- Michael F. Gerhards (ORCID: https://orcid.org/0000-0001-6588-4917)
- Blaž Trotovšek (ORCID: https://orcid.org/0000-0002-0791-2083)
- Emanuele Felli (ORCID: https://orcid.org/0000-0002-6510-1457)
- Abdul Hakeem (ORCID: https://orcid.org/0000-0002-4546-9078)
- Ahmet Çöker (ORCID: https://orcid.org/0000-0002-5573-7216)
- Edoardo Saladino
- Joris I. Erdmann (ORCID: https://orcid.org/0000-0001-8233-1505)
- Frederik Berrevoet (ORCID: https://orcid.org/0000-0002-3575-5345)
- Lyle Burdine (ORCID: https://orcid.org/0000-0002-5892-2281)
- Masayuki Ohtsuka (ORCID: https://orcid.org/0000-0002-5091-1078)
- R. Méméo
- Gaetano Piccolo (ORCID: https://orcid.org/0000-0002-4942-7705)
- Leyre Serrablo
- Shantanu Joglekar (ORCID: https://orcid.org/0000-0003-4041-7620)
- Donzília Sousa Silva (ORCID: https://orcid.org/0000-0002-7165-3581)
- Teiichi Sugiura (ORCID: https://orcid.org/0000-0001-7163-4084)
- Tomoyuki Abe (ORCID: https://orcid.org/0000-0001-6859-7614)
- Deep J. Malde
- Sophie Rozwadowski
- Edoardo Maria Muttillo (ORCID: https://orcid.org/0000-0003-3562-0392)
- Philip de Reuver
- Carlo Alberto Schena (ORCID: https://orcid.org/0000-0003-1136-1103)
- Paul Gibbs (ORCID: https://orcid.org/0000-0003-2193-5377)
- Savvas Tsaramanidis (ORCID: https://orcid.org/0000-0001-6408-5494)
- Guillaume Martel (ORCID: https://orcid.org/0000-0002-1242-2601)
- Georgi Atanasov (ORCID: https://orcid.org/0000-0001-8239-4207)
- Jessica Keilson
- Oliver Strobel (ORCID: https://orcid.org/0000-0001-5100-8449)
- S. Z. Sayed Hassen
- Shibojit Talukder (ORCID: https://orcid.org/0000-0003-2083-2886)
- Matthew Dixon (ORCID: https://orcid.org/0000-0001-7920-2278)
- X. De Aretxabala
- Natalie Petruch (ORCID: https://orcid.org/0000-0002-8769-744X)
- Jun Kit Koong
- Viswakumar Prabakaran
- Manisekar Subramaniam
- Abhirup Banerjee (ORCID: https://orcid.org/0000-0001-8198-5128)
- Arkaitz Perfecto Valero (ORCID: https://orcid.org/0000-0002-5304-8142)
- Daniel Galun
- Maria Eduarda
- Colin Noel (ORCID: https://orcid.org/0000-0003-2344-415X)
- Klaus Kaczirek
- Stefan Heinrich (ORCID: https://orcid.org/0000-0001-9961-0957)
- Urban Stupan
- Andries E. Braat (ORCID: https://orcid.org/0000-0003-3615-2690)
- George Molina (ORCID: https://orcid.org/0000-0001-6516-2121)
- Miguel Ángel Suárez Muñóz (ORCID: https://orcid.org/0000-0001-9012-8670)
- Raffaele Dalla Valle (ORCID: https://orcid.org/0000-0003-4847-6924)
- Georgios Tsoulfas (ORCID: https://orcid.org/0000-0001-5043-7962)
- Leah Monette
- Akshay Anand (ORCID: https://orcid.org/0000-0002-8715-4568)
- Julie Périnel (ORCID: https://orcid.org/0000-0002-9040-9728)
- Dimitrios Moris (ORCID: https://orcid.org/0000-0002-5276-0699)
- Antonios Morsi-Yeroyannis (ORCID: https://orcid.org/0000-0002-6579-9488)
- Dolores López Garnica
- Abu Bakar Hafeez Bhatti (ORCID: https://orcid.org/0000-0002-4875-603X)
- Mickaël Lesurtel (ORCID: https://orcid.org/0000-0003-2397-4599)
- Lucio Urbani (ORCID: https://orcid.org/0000-0002-4075-6123)
- Gerardo Blanco‐Fernández (ORCID: https://orcid.org/0000-0003-4845-5306)
- Michele Mazzola (ORCID: https://orcid.org/0000-0002-3546-197X)
- Catherine Teh (ORCID: https://orcid.org/0000-0002-2422-2236)
- Alfredo Guglielmi (ORCID: https://orcid.org/0000-0003-1713-4307)
- Bodil Andersson (ORCID: https://orcid.org/0000-0001-5591-0659)
- Marc M. Mankarious (ORCID: https://orcid.org/0000-0001-8810-2762)
- Aistė Gulla (ORCID: https://orcid.org/0000-0003-2433-3603)
- Ambareen Kausar (ORCID: https://orcid.org/0000-0003-0234-9321)
- Pantelis Antonakis (ORCID: https://orcid.org/0000-0002-7855-1721)
- Benjamin Chan (ORCID: https://orcid.org/0000-0001-9500-2380)
- Mario De Bellis (ORCID: https://orcid.org/0000-0001-7932-5921)
- Petros Barmpounakis (ORCID: https://orcid.org/0000-0002-1020-3886)
- Prabin Bikram Thapa (ORCID: https://orcid.org/0000-0003-3304-2410)
- Daniel Croagh (ORCID: https://orcid.org/0000-0002-6430-6741)
- Vishwanath Siddagangaiah
- Panagiotis Dorovinis (ORCID: https://orcid.org/0000-0002-4861-8753)
- F. Bartsch (ORCID: https://orcid.org/0000-0001-6090-2530)
- Asara Thepbunchonchai (ORCID: https://orcid.org/0000-0001-7508-2715)
- Louisa Bolm (ORCID: https://orcid.org/0000-0002-1612-1857)
- Felice Giuliante (ORCID: https://orcid.org/0000-0003-2087-2589)
- Alessandro Parente (ORCID: https://orcid.org/0000-0001-5506-224X)
- Yeong Sing Lee
- Artūrs Ozoliņš
- Linda Lundgren (ORCID: https://orcid.org/0000-0002-1927-2482)
- Jeroen Hagendoorn (ORCID: https://orcid.org/0000-0001-8737-3923)
- Ibrahım Umar Garzali (ORCID: https://orcid.org/0000-0002-9797-851X)
- Aali J. Sheen (ORCID: https://orcid.org/0000-0001-6054-5385)
- Freek Daams (ORCID: https://orcid.org/0000-0001-6323-6342)
- José Manuel Ramia (ORCID: https://orcid.org/0000-0003-1186-953X)
- Abhinav Arun Sonkar (ORCID: https://orcid.org/0000-0002-5093-1992)
- Nagappan Kumar (ORCID: https://orcid.org/0000-0001-8324-9685)
- Maite Albiol
- Arash Nickkholgh
- Nikolaos Demiris
- M. de Boer
- Emre Bozkurt (ORCID: https://orcid.org/0000-0001-7971-3772)
- Chutwichai Tovikkai (ORCID: https://orcid.org/0000-0002-4412-0528)
- Jean-Baptiste Lequeu
- Faris Soliman (ORCID: https://orcid.org/0000-0002-9283-0006)
- Rajendra Prasad (ORCID: https://orcid.org/0000-0001-6061-001X)
- Andras Fulop
- Daniel B. Hoffman (ORCID: https://orcid.org/0000-0002-2302-6786)
- Simona Beretta (ORCID: https://orcid.org/0000-0002-8007-360X)
- D.M. D'Souza (ORCID: https://orcid.org/0000-0002-4523-1422)
- Anita Balakrishnan (ORCID: https://orcid.org/0000-0002-9172-3938)
- Manon Viennet (ORCID: https://orcid.org/0000-0002-6420-0066)
- Amit Gupta (ORCID: https://orcid.org/0000-0002-4847-4120)
- Deepak Sharma (ORCID: https://orcid.org/0000-0001-7612-3486)
- Jack L. Martin (ORCID: https://orcid.org/0000-0001-8709-0392)
- Li Xu (ORCID: https://orcid.org/0000-0003-2878-302X)
- Per Sandström (ORCID: https://orcid.org/0000-0002-1635-2583)
- Michael Silva (ORCID: https://orcid.org/0000-0003-4575-3519)
- Mohamed Amine Said
- Manas Kumar Roy (ORCID: https://orcid.org/0000-0003-3546-2451)
- Alberto Quaglia (ORCID: https://orcid.org/0000-0002-3333-3579)
- Michał Skalski (ORCID: https://orcid.org/0000-0003-2304-157X)
- Saurabh Singh (ORCID: https://orcid.org/0000-0003-3134-7165)
- Víctor López López (ORCID: https://orcid.org/0000-0002-3916-995X)
- Lillian Taylor
- Mario Giuffrida
- Zain Hajee
- Zhanyi Kee
- Andrea Ruzzenante
- Mante Smig
- Peter van de Boezem
- Alyn Crutchley
- Patrick Pessaux
- Zhiying Yang (ORCID: https://orcid.org/0009-0003-8670-0293)
- Francesco Razionale
- Andrea Belli
- Maria Jesús Castro Santiago
- Ricardo Robles Campos
- Paleswan Joshi Lakhey (ORCID: https://orcid.org/0000-0003-1287-7101)
- Guido Torzilli
- Ricardo Balestri
- Konstantinos Bramis (ORCID: https://orcid.org/0000-0002-2744-3042)
- Verónica Araya
- Mustapha Adham
- Luis Gil
- Pueya Rashid Nashidengo
- Nassir Alhaboob
- Jörg Kleef
- Roberto Hernandez‐Alejandro
- Mikel Prieto Calvo
- Lorenzo Serafini
- Gabriela Echeverría Bauer
- María Conde Rodríguez
- Siong S Liau
- Mathieu Bonal
- Simon Harper
- Brett Knowles
- Eduardo Figueroa Rivera
- Aklile Workneh
- Natalia Ruiz
Institutions
- Koç University (TR)
- Lund University (SE)
- University of Cambridge (GB)
- Universidad de Buenos Aires (AR)
- University of the Free State (ZA)
- Argerich Hospital (AR)
- Sahlgrenska University Hospital (SE)
- Clínica Alemana (CL)
- Cambridge University Hospitals NHS Foundation Trust (GB)
- Hospital Universitario Miguel Servet (ES)
- Skåne University Hospital (SE)
- Complejo Asistencial Sótero del Río (CL)
- Robert H. Lurie Comprehensive Cancer Center of Northwestern University
- Athens University of Economics and Business (GR)
- University of Gothenburg (SE)
Publication Details
- Journal
- BJS Open
- Published
- 2025-05-07
- DOI
- https://doi.org/10.1093/bjsopen/zraf056
- Citations
- 2
- Primary Topic
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Type
- article
- Field-Weighted Citation Impact
- 4.01
Funders
- Brigham and Women's Hospital
- University of Pennsylvania
- Emory University
- University of Rochester
- Pennsylvania State University
- University of Arkansas for Medical Sciences
- McMaster University
- Tribhuvan University
- Amsterdam University Medical Centers
- University of Oxford
- Universiteit Leiden
- Semmelweis Egyetem
- Universitair Medisch Centrum Utrecht
- Royal Adelaide Hospital
- Leids Universitair Medisch Centrum
- Universitair Medisch Centrum Groningen
- National and Kapodistrian University of Athens
- Universidad de Buenos Aires
- Universidad de Chile
- Oxford University Hospitals NHS Foundation Trust
- Università degli Studi di Verona
- Universidade Federal do Rio de Janeiro
- Centro Hospitalar Universitário do Porto
- Universidad de Extremadura
- Lietuvos Sveikatos Mokslų Universitetas
- Koç Üniversitesi
- St Vincent's Hospital Melbourne
- Penn State College of Medicine
- Universitätsmedizin der Johannes Gutenberg-Universität Mainz
- NIH Clinical Center