Comprehensive Single-Cell RNA Atlas of Human Laryngeal Normal, Preneoplastic, and Tumorigenic States
Our single-cell RNA sequencing and spatial transcriptomics analyses revealed the cellular heterogeneity underlying benign, precancerous, and malignant laryngeal lesions. We identified epithelial subclusters in VCL with malignant potential and observed shared immunosuppressive features with LSCC, suggesting their role in disease progression. These findings provide valuable insights into the molecular transition from VCL to LSCC and emphasize potential targets for early diagnosis and therapeutic intervention.
Authors
- Shui‐Hong Zhou (ORCID: https://orcid.org/0000-0002-7163-2289)
- Yang‐Yang Bao (ORCID: https://orcid.org/0000-0001-7857-9954)
- Li‐Bo Dai
- Zhe Chen (ORCID: https://orcid.org/0000-0003-3676-2771)
- Z. Fu (ORCID: https://orcid.org/0009-0008-5597-1177)
- Heng-Chao Chen (ORCID: https://orcid.org/0000-0001-8881-8744)
- Jiang‐Tao Zhong (ORCID: https://orcid.org/0009-0005-2225-599X)
Institutions
- First Affiliated Hospital Zhejiang University (CN)
- Zhejiang University (CN)
Publication Details
- Journal
- Clinical Cancer Research
- Published
- 2025-05-23
- DOI
- https://doi.org/10.1158/1078-0432.ccr-24-3679
- Citations
- 3
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 2.81
Funders
- National Natural Science Foundation of China