A Phase II Study of Neoadjuvant GVAX and Cyclophosphamide Combined with Nivolumab and SBRT Followed by Surgery in Borderline Resectable Pancreatic Adenocarcinoma
The addition of combined immunotherapy and SBRT was safe and feasible in this patient population. No difference was observed in the mean CD8 T-cell density between study patients and historic controls. These findings support the need for better characterization of how neoadjuvant immunotherapy may shift the phenotype of the PDAC TME.
Authors
- Arsen Osipov (ORCID: https://orcid.org/0000-0002-9000-7040)
- Ben George (ORCID: https://orcid.org/0000-0002-9667-9833)
- Matthew Guo (ORCID: https://orcid.org/0000-0003-4741-7463)
- Jeanne Harrison
- Robert A. Anders (ORCID: https://orcid.org/0000-0002-2363-9072)
- Amol Narang (ORCID: https://orcid.org/0000-0002-0876-4967)
- Ana De Jesus‐Acosta (ORCID: https://orcid.org/0000-0002-3225-3024)
- Daniel A. Laheru (ORCID: https://orcid.org/0000-0001-6646-0200)
- Richard A. Burkhart (ORCID: https://orcid.org/0000-0003-1087-0870)
- Elizabeth M. Jaffee (ORCID: https://orcid.org/0000-0003-3841-6549)
- Elizabeth D. Thompson (ORCID: https://orcid.org/0000-0003-4633-843X)
- Rose Parkinson (ORCID: https://orcid.org/0009-0003-4960-0402)
- Mark Yarchoan (ORCID: https://orcid.org/0000-0003-4401-0748)
- Jin Peng He (ORCID: https://orcid.org/0000-0001-9149-2247)
- Hanfei Qi (ORCID: https://orcid.org/0000-0002-0072-5752)
- Parul Agarwal (ORCID: https://orcid.org/0000-0001-9549-5023)
- Lei Zheng (ORCID: https://orcid.org/0000-0003-4163-2541)
- Hao Wang (ORCID: https://orcid.org/0000-0001-6489-6940)
- Anna Ferguson (ORCID: https://orcid.org/0000-0003-2739-8445)
- Christina Mitchell
- Kabeer Munjal
Institutions
- Cedars-Sinai Medical Center (US)
- Froedtert Hospital (US)
- Johns Hopkins University (US)
- Medical College of Wisconsin (US)
- Johns Hopkins Medicine (US)
- Johns Hopkins Hospital (US)
- Sidney Kimmel Comprehensive Cancer Center (US)
- University of Pennsylvania (US)
Publication Details
- Journal
- Clinical Cancer Research
- Published
- 2025-05-23
- DOI
- https://doi.org/10.1158/1078-0432.ccr-24-3403
- Citations
- 3
- Primary Topic
- Pancreatic and Hepatic Oncology Research
- Type
- article
- Field-Weighted Citation Impact
- 3.14