The Combination of Afternoon and Midnight Salivary Cortisol Improves the Diagnosis of Cushing Syndrome
The evaluation of the 1400 h and 2400 h assays led to detection of the total number of patients with Cushing syndrome. Salivary cortisol curve analysis is a non-invasive diagnostic strategy associated with elevated positive predictive value for hypercortisolism capable of enabling diagnosis. In addition, it can be considered for management of patient outcomes and monitoring of Cushing syndrome pharmacological treatment.
Authors
- Roberta Maggio (ORCID: https://orcid.org/0000-0001-8319-4418)
- Donatella De Bernardini
- Pina Lardo
- Antonio Stigliano (ORCID: https://orcid.org/0000-0002-7143-0775)
- Maurizio Simmaco (ORCID: https://orcid.org/0000-0003-4164-1472)
- Luana Lionetto (ORCID: https://orcid.org/0000-0002-5272-6642)
- Giuseppe Costanzi
- Gerardo Salerno (ORCID: https://orcid.org/0000-0002-6597-1452)
- Irene Biondo
- Maria Elena Aloini
- Guido Roberto
- Francesca Ricci (ORCID: https://orcid.org/0009-0008-3396-3774)
Institutions
- Azienda Ospedaliera Sant'Andrea (IT)
- Sapienza University of Rome (IT)
Publication Details
- Journal
- The American Journal of Medicine
- Published
- 2025-05-23
- DOI
- https://doi.org/10.1016/j.amjmed.2025.04.035
- Citations
- 2
- Primary Topic
- Pituitary Gland Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 2.59