Antiphospholipid antibodies inhibit the migration and invasion of trophoblast cells by suppressing the JNK/C-Jun/MMP1 signaling pathway
APL downregulated MMP1 expression by suppressing the JNK/C-Jun signaling pathway in trophoblast cells, thereby reducing their migratory and invasive capabilities. This represent a potential pathogenic mechanism contributing to adverse pregnancy outcomes in APS patients, highlighting possible therapeutic targets for intervention in APS management.
Authors
- Hongchao Liu (ORCID: https://orcid.org/0000-0001-5241-1002)
- Shuo Yang (ORCID: https://orcid.org/0000-0001-6894-0793)
- Boxin Yang
- Zhen Xu (ORCID: https://orcid.org/0000-0002-5594-1778)
- Qingchen Wang (ORCID: https://orcid.org/0000-0003-1708-5656)
- Jiao Qiao (ORCID: https://orcid.org/0000-0003-4631-805X)
- Yuan Tan (ORCID: https://orcid.org/0000-0002-6370-4078)
- He Wang
- Weimin Feng
- Liyan Cui (ORCID: https://orcid.org/0000-0003-1870-3997)
- Qi Liu (ORCID: https://orcid.org/0000-0002-8485-3582)
- Zhongxin Li (ORCID: https://orcid.org/0000-0002-6375-1667)
- Jingjin Tao
- Chong Wang (ORCID: https://orcid.org/0009-0007-4414-5147)
- Qian Zhang (ORCID: https://orcid.org/0000-0001-5975-9781)
Institutions
- Peking University (CN)
- Peking University Third Hospital (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-05-23
- DOI
- https://doi.org/10.1186/s12967-025-06596-y
- Citations
- 4
- Primary Topic
- Reproductive System and Pregnancy
- Type
- article
- Field-Weighted Citation Impact
- 3.19
Funders
- National Natural Science Foundation of China