Machine learning explores the prognostic and immuno-oncological impact of mitochondrial unfolded protein response in CESC
Our findings establish ATF5 as both a favorable prognostic marker and a key immune response regulator in CESC. Its influence on the tumor microenvironment and treatment response suggests potential therapeutic applications. These insights into UPR<sup>mt</sup>'s role in CESC provide new directions for developing personalized treatment strategies.
Authors
- Hung‐Yu Lin (ORCID: https://orcid.org/0000-0002-9035-5408)
- Yen‐Hsiang Chang (ORCID: https://orcid.org/0000-0003-4491-0076)
- Hsing‐Ju Wu (ORCID: https://orcid.org/0000-0002-2005-495X)
- Keh-Sen Liu (ORCID: https://orcid.org/0000-0002-9504-0413)
Institutions
- Kaohsiung Chang Gung Memorial Hospital (TW)
- Chang Bing Show Chwan Memorial Hospital (TW)
- Mackay Junior College of Medicine, Nursing and Management (TW)
Publication Details
- Journal
- Discover Oncology
- Published
- 2025-05-23
- DOI
- https://doi.org/10.1007/s12672-025-02723-9
- Citations
- 1
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 1.52
Funders
- Chang Bing Show Chwan Memorial Hospital