Association of DNA damage response signals and oxidative stress status with nivolumab efficacy in patients with Head and Neck Squamous Cell Carcinoma
Our findings demonstrate that oxidative stress and deregulated DDR-related signals measured in PBMCs from HNSCC patients at baseline correlate with response to nivolumab and, if further validated, may be exploited as novel non-invasive biomarkers and the design of clinical trials.
Authors
- Panagiota Economopoulou
- Ioannis G. Panayiotides (ORCID: https://orcid.org/0000-0001-7339-8193)
- Niki Gavrielatou (ORCID: https://orcid.org/0000-0003-1380-6831)
- Periklis G. Foukas (ORCID: https://orcid.org/0000-0002-6053-7841)
- David L. Rimm (ORCID: https://orcid.org/0000-0001-5820-4397)
- Christina Papanikolaou (ORCID: https://orcid.org/0000-0003-3836-6932)
- Μaria Anastasiou (ORCID: https://orcid.org/0000-0003-0047-8090)
- Aris Spathis (ORCID: https://orcid.org/0000-0001-8867-3661)
- Anastasios Kyriazoglou (ORCID: https://orcid.org/0000-0003-3222-4060)
- George-Romanos P. Foukas
- Amanda Psyrri (ORCID: https://orcid.org/0000-0002-4321-766X)
- Ioannis Kotsantis (ORCID: https://orcid.org/0000-0002-4666-4852)
- Vassilis L. Souliotis (ORCID: https://orcid.org/0000-0002-2945-1329)
- Myrto Moutafi
- Ioannis M. Lelegiannis (ORCID: https://orcid.org/0009-0009-8388-5281)
Institutions
- Centre Hospitalier Universitaire Vaudois (CH)
- Yale University (US)
- National Hellenic Research Foundation (GR)
- University General Hospital Attikon (GR)
Publication Details
- Journal
- British Journal of Cancer
- Published
- 2025-05-23
- DOI
- https://doi.org/10.1038/s41416-025-03032-2
- Citations
- 4
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 4.18
Funders
- Hellenic Society of Medical Oncology