Changes in the FXR-cistrome and alterations in bile acid physiology in Wilson disease
We identified novel FXR-occupancy across the genome that varied in parenchymal and non-parenchymal cells, demonstrating complex FXR regulation of metabolic and hepatocellular stress pathways in Atp7b-/- mice. Dynamic changes in FXR activity support our novel finding of altered bile acid metabolism in Atp7b-/- mice and WD patients.
Authors
- Hari Krishna Yalamanchili (ORCID: https://orcid.org/0000-0001-9892-3054)
- Nagireddy Putluri (ORCID: https://orcid.org/0000-0003-4488-7400)
- Vasanta Putluri (ORCID: https://orcid.org/0000-0001-7943-2209)
- Clavia Ruth Wooton‐Kee (ORCID: https://orcid.org/0000-0003-4485-0747)
- Ayse K. Coskun (ORCID: https://orcid.org/0000-0002-9339-3418)
- Monica Narvaez Rivas
- Michael L. Schilsky (ORCID: https://orcid.org/0000-0001-9043-0554)
- Prasun K. Jalal (ORCID: https://orcid.org/0000-0001-5353-2324)
- David D. Moore (ORCID: https://orcid.org/0000-0002-5151-9748)
- Islam Mohamed (ORCID: https://orcid.org/0000-0002-9408-4895)
- Kenneth D.R. Setchell
- Manal M. Hassan (ORCID: https://orcid.org/0000-0002-8413-449X)
Institutions
- Cincinnati Children's Hospital Medical Center (US)
- The University of Texas MD Anderson Cancer Center (US)
- Baylor College of Medicine (US)
- Yale University (US)
- Neurological Research Institute (US)
- Children's Nutrition Research Center at Baylor College of Medicine (US)
- Texas Children's Hospital (US)
- University of Cincinnati Medical Center (US)
- University of California, Berkeley (US)
Publication Details
- Journal
- Hepatology Communications
- Published
- 2025-05-23
- DOI
- https://doi.org/10.1097/hc9.0000000000000707
- Citations
- 1
- Primary Topic
- Drug Transport and Resistance Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 1.05
Funders
- U.S. Department of Agriculture
- National Institutes of Health