Cholangiocarcinoma cells direct fatty acids to support membrane synthesis and modulate macrophage phenotype
Our results reveal a profound alteration in the lipid content of iCCA tissues and demonstrate that FA accumulation prompts iCCA aggressiveness by supporting membrane biogenesis, generating bioactive lipids that boost proliferation, and by modifying macrophage phenotype.
Authors
- Delfina Tosi (ORCID: https://orcid.org/0000-0002-6130-2665)
- Anna Caretti (ORCID: https://orcid.org/0000-0001-6140-6969)
- Barbara Oliviero (ORCID: https://orcid.org/0000-0002-0532-4608)
- Michele Dei (ORCID: https://orcid.org/0000-0001-7359-8558)
- Marcello Maestri (ORCID: https://orcid.org/0000-0002-5693-9151)
- Aı́da Zulueta (ORCID: https://orcid.org/0000-0001-8295-6847)
- Gaetano Piccolo (ORCID: https://orcid.org/0000-0002-4942-7705)
- Monica Falleni (ORCID: https://orcid.org/0000-0002-7905-1227)
- Ana Lleò (ORCID: https://orcid.org/0000-0002-0561-7902)
- Matteo Barabino (ORCID: https://orcid.org/0000-0001-9525-9063)
- Stefania Mantovani (ORCID: https://orcid.org/0000-0002-5885-2842)
- Camillo Morano (ORCID: https://orcid.org/0000-0003-0352-2819)
- Camilla Barbero Mazzucca (ORCID: https://orcid.org/0000-0003-2605-5037)
- Cristiana Soldani (ORCID: https://orcid.org/0000-0001-5041-9588)
- Jesús M. Bañales (ORCID: https://orcid.org/0000-0002-5224-2373)
- Linda Montavoci (ORCID: https://orcid.org/0000-0001-7484-5311)
- Mario U. Mondelli (ORCID: https://orcid.org/0000-0003-1811-3153)
- Paolo Pietro Bianchi (ORCID: https://orcid.org/0000-0002-2690-3502)
- Matteo Donadon (ORCID: https://orcid.org/0000-0003-0296-7648)
- Sara Penati (ORCID: https://orcid.org/0009-0001-0744-0936)
- Riccardo Sinella
- Annalisa Chiocchetti
Institutions
- Ikerbasque (ES)
- Università degli Studi del Piemonte Orientale “Amedeo Avogadro” (IT)
- Humanitas University (IT)
- University of the Basque Country (ES)
- University of Milan (IT)
- University of Pavia (IT)
- Istituti Clinici Scientifici Maugeri (IT)
- Azienda Ospedaliero Universitaria Maggiore della Carita (IT)
- Policlinico San Matteo Fondazione (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- IRCCS Humanitas Research Hospital (IT)
- Universidad de Navarra (ES)
Publication Details
- Journal
- Hepatology Communications
- Published
- 2025-05-23
- DOI
- https://doi.org/10.1097/hc9.0000000000000717
- Citations
- 3
- Primary Topic
- Cancer, Lipids, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 2.81
Funders
- Gilead Sciences
- Università degli Studi di Milano
- Incyte
- European Commission
- Ministero della Salute
- Papua New Guinea University of Technology
- Ipsen
- Instituto de Salud Carlos III