GPx3 marks adipocyte lineage commitment in bone marrow stromal cells
These findings indicate that GPx3 is closely associated with adipocyte lineage commitment within the bone marrow microenvironment and may serve as a key modulator of BMSC fate. This study underscores the potential role of antioxidant enzymes such as GPx3 in the regulation of age-related bone-fat imbalance and highlights their relevance in metabolic bone disorders.
Authors
- Lichuang Wu
- Chengyu Zhou (ORCID: https://orcid.org/0000-0002-3398-2288)
- Zhongxiang Wang (ORCID: https://orcid.org/0000-0003-1984-3852)
- Yang‐Yang Hu (ORCID: https://orcid.org/0000-0001-7992-836X)
- Li Mao (ORCID: https://orcid.org/0000-0002-1556-7793)
- Xiaojun Chen (ORCID: https://orcid.org/0000-0002-8939-9657)
- Kai Chen (ORCID: https://orcid.org/0000-0001-6850-1723)
- Zhiyang Xu (ORCID: https://orcid.org/0000-0001-8347-6554)
Institutions
- The University of Western Australia (AU)
- Wenzhou Medical University (CN)
- First Affiliated Hospital of Wenzhou Medical University (CN)
Publication Details
- Journal
- Journal of Orthopaedic Surgery and Research
- Published
- 2025-05-23
- DOI
- https://doi.org/10.1186/s13018-025-05908-8
- Citations
- 2
- Primary Topic
- Adipose Tissue and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 2.33
Funders
- Arthritis Australia
- National Natural Science Foundation of China