The performance of plasma p‐tau217 in Black middle‐aged and older adults
Plasma tau phosphorylated at threonine 217 (p-tau217) was tested in a sample of Black middle-aged and older adults. Level of p-tau217 was higher in impaired kidney function and cardiovascular disease. Obesity and diabetes were not related to p-tau217. Level of p-tau217 was higher in amyloid- and tau-PET-positive status. Plasma p-tau217 showed good receiver-operating characteristic area under the curve for abnormal amyloid- and tau-PET.
Authors
- Megan Zuelsdorff (ORCID: https://orcid.org/0000-0002-9632-475X)
- Fabu P. Carter
- Rebecca L. Koscik (ORCID: https://orcid.org/0000-0003-0025-744X)
- Carey Elizabeth Gleason (ORCID: https://orcid.org/0000-0001-6210-4671)
- Derek Norton (ORCID: https://orcid.org/0000-0003-2554-5499)
- Diane C. Gooding (ORCID: https://orcid.org/0000-0002-0498-9472)
- Rachael E. Wilson (ORCID: https://orcid.org/0000-0003-4197-7777)
- Shenikqua Bouges (ORCID: https://orcid.org/0000-0002-4452-0548)
- Gilda E. Ennis (ORCID: https://orcid.org/0000-0003-4329-0215)
- Sanjay Asthana (ORCID: https://orcid.org/0000-0002-3298-6324)
- Sterling C. Johnson
- Henrik Zetterberg
Institutions
- University of Wisconsin–Madison (US)
- Sahlgrenska University Hospital (SE)
- Geriatric Research Education and Clinical Center (US)
- UK Dementia Research Institute (GB)
- National Hospital for Neurology and Neurosurgery (GB)
- University College London (GB)
- University of Gothenburg (SE)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-05-01
- DOI
- https://doi.org/10.1002/alz.70288
- Citations
- 7
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 10.30
Funders
- Alzheimer's Association
- Alzheimer's Drug Discovery Foundation
- Familjen Erling-Perssons Stiftelse
- Cure Alzheimer's Fund
- Stiftelsen för Gamla Tjänarinnor
- EU Joint Programme – Neurodegenerative Disease Research
- Hjärnfonden
- Vetenskapsrådet
- UK Dementia Research Institute
- Horizon 2020 Framework Programme
- HORIZON EUROPE Innovative Europe
- H2020 Marie Skłodowska-Curie Actions