STING deletion protects against amyloid β–induced Alzheimer's disease pathogenesis
Stimulator of interferon genes (STING) deficiency in the 5xFAD mouse model of Alzheimer's disease-related amyloidosis results in decreased amyloid beta (Aβ) deposition and altered microglial activation status. Protection against amyloidosis in STING-deficient 5xFAD mice is associated with decreased expression of genes involved in type I IFN signaling, improved neuronal health, and reduced levels of oxidative stress. Loss of STING in 5xFAD mice leads to improved spatial learning and memory.
Authors
- Katherine R. Bruch
- Hannah Ennerfelt (ORCID: https://orcid.org/0000-0003-4861-0740)
- Katelyn A. Moore
- Maureen N. Cowan (ORCID: https://orcid.org/0000-0001-6842-8175)
- Aman Mangalmurti (ORCID: https://orcid.org/0000-0002-7588-4344)
- Olivia Campbell
- Jessica M. Thanos (ORCID: https://orcid.org/0000-0001-7984-5361)
- Nagaraj Kerur (ORCID: https://orcid.org/0000-0001-5040-2129)
- John R. Lukens (ORCID: https://orcid.org/0000-0002-6795-0866)
- Nick R. Natale (ORCID: https://orcid.org/0000-0001-5677-0977)
Institutions
- The Ohio State University Wexner Medical Center (US)
- Massachusetts General Hospital (US)
- University of Virginia (US)
- Stanford University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-05-01
- DOI
- https://doi.org/10.1002/alz.70305
- Citations
- 14
- Primary Topic
- interferon and immune responses
- Type
- article
- Field-Weighted Citation Impact
- 11.16
Funders
- Alzheimer's Association
- Cure Alzheimer's Fund
- Owens Family Foundation
- National Institutes of Health
- National Institute on Aging
- National Institute of Neurological Disorders and Stroke