Effect and mechanism of Nintedanib on acute and chronic radiation-induced lung injury in mice
(1) Nintedanib can improve the general condition of mice with acute and chronic radiation-induced lung injury and reduce pathological damage to lung tissue. (2) Nintedanib may exert a protective effect on mice with acute and chronic radiation-induced lung injury by downregulating the TGF-β1/Smad2 signaling pathway, thereby inhibiting inflammatory and fibrotic responses.
Authors
- Yujie Zhai
- Kun Zhang (ORCID: https://orcid.org/0000-0001-9989-9260)
- Lu Ren (ORCID: https://orcid.org/0000-0001-5730-824X)
Institutions
- Shandong University of Aeronautics (CN)
- Zhuzhou Central Hospital (CN)
Publication Details
- Journal
- PLoS ONE
- Published
- 2025-05-23
- DOI
- https://doi.org/10.1371/journal.pone.0324339
- Citations
- 1
- Primary Topic
- Effects of Radiation Exposure
- Type
- article
- Field-Weighted Citation Impact
- 1.36
Funders
- Science and Technology Support Plan for Youth Innovation of Colleges and Universities of Shandong Province of China