Functional Humoral Response During Intranasal Convalescent Plasma Prophylaxis for Severe Acute Respiratory Syndrome Coronavirus 2
Our findings demonstrate that intranasal CCP prophylaxis prevents lung disease in hamsters by restraining the infection to the upper respiratory tract, while still promoting a functional humoral immune response that protects against reinfection.
Authors
- Tania Maes (ORCID: https://orcid.org/0000-0002-3037-6928)
- Caro Verbrugghe (ORCID: https://orcid.org/0009-0005-9245-8880)
- Elise Wouters (ORCID: https://orcid.org/0000-0001-9117-4759)
- Birgit Weynand (ORCID: https://orcid.org/0000-0003-4246-6303)
- Rana Abdelnabi (ORCID: https://orcid.org/0000-0001-9771-7312)
- Hendrik B. Feys (ORCID: https://orcid.org/0000-0003-0052-8852)
- Philippe Vandekerckhove (ORCID: https://orcid.org/0000-0001-7709-0153)
- Johan Neyts (ORCID: https://orcid.org/0000-0002-0033-7514)
Institutions
- Western Cape Department of Health (ZA)
- American Red Cross (US)
- Rega Institute for Medical Research (BE)
- Stellenbosch University (ZA)
- Global Virus Network (US)
- Ghent University Hospital (BE)
- Ghent University (BE)
- CrossLang (Belgium) (BE)
- KU Leuven (BE)
Publication Details
- Journal
- The Journal of Infectious Diseases
- Published
- 2025-05-23
- DOI
- https://doi.org/10.1093/infdis/jiaf273
- Primary Topic
- SARS-CoV-2 and COVID-19 Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Agentschap Innoveren en Ondernemen
- Fonds Wetenschappelijk Onderzoek
- Universitair Ziekenhuis Gent
- Universiteit Gent
- Vlaamse regering