Synthesis of 3,4-Fused Pyrroles with Seven-Membered Carbocycles via Cascade C–C σ-Bond Cleavage/Intramolecular Cyclization Reactions
A novel tandem reaction involving amino-substituted ynones and cyclic carbonyls has been developed, efficiently synthesizing 3,4-fused pyrroles with seven-membered carbocycles by a one-pot method. This reaction proceeds through a cascade ring-expansion of cyclic carbonyls, followed by intramolecular cyclization reactions. This metal-free strategy enables the concurrent construction of the medium-sized ring and the pyrrole ring, exhibiting a high step economy.
Authors
- Qiongwen Kang (ORCID: https://orcid.org/0000-0002-1539-1652)
- Zongkang Wang (ORCID: https://orcid.org/0000-0002-8024-4587)
- Peng He (ORCID: https://orcid.org/0009-0002-2457-5039)
- Nana Fei (ORCID: https://orcid.org/0000-0002-3531-622X)
- Yanjun Wang (ORCID: https://orcid.org/0009-0001-9975-4376)
- Yanzhong Li (ORCID: https://orcid.org/0000-0002-2898-3075)
- Lingkai Kong (ORCID: https://orcid.org/0000-0001-6480-513X)
Institutions
- Linyi University (CN)
- East China Normal University (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2025-05-23
- DOI
- https://doi.org/10.1021/acs.orglett.5c01607
- Citations
- 1
- Primary Topic
- Advanced Synthetic Organic Chemistry
- Type
- article
- Field-Weighted Citation Impact
- 0.94
Funders
- National Natural Science Foundation of China